Lanthanide Metal (III) Ions for Remarkably Efficient Hydrolyses of Phosphodiester Linkages in Biomaterials

Makoto Komiyama, Morio Yashiro, Yoichi Matsumoto, Jun Sumaoka, Kazunari Matsumura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lanthanide metal(IH) ions remarkably catalyze the hydrolysis of phosphodiester linkages in DNA, RNA, and adenosine 3′, 5′-cyclic phosphate. The magnitudes of acceleration range from 104 to 1012 fold. With the use of Ce(III) ion (0. 01 mol-dm-3), the phosphodiester linkages in linear DNAs are hydrolyzed for the first time nonenzymatically (half-life 3. 6 h at pH 7. 2, 50°C). Furthermore, the linkages in both RNA and adenosine 3′, 5′-cyclic phosphate are efficiently hydrolyzed at pH 8.0, 30°C with the half-lives 10 min (by Tm(I)) and 36 \ seconds (by Ce(III)), respectively. Non-lanthanide metal ions show virtually no catalysis : the superb catalysis is specific for lanthanide metal ions. These results indicate high potentialities of the metal ions as the catalytic centers for the artificial enzymes which are applicable to regulation of various bio-reactions.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalNippon Kagaku Kaishi
Volume1993
Issue number5
DOIs
Publication statusPublished - 1993
Externally publishedYes

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Lanthanoid Series Elements
Biocompatible Materials
Rare earth elements
Biomaterials
Metal ions
Hydrolysis
RNA
Adenosine
Catalysis
Phosphates
DNA
Enzymes
Ions

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Lanthanide Metal (III) Ions for Remarkably Efficient Hydrolyses of Phosphodiester Linkages in Biomaterials. / Komiyama, Makoto; Yashiro, Morio; Matsumoto, Yoichi; Sumaoka, Jun; Matsumura, Kazunari.

In: Nippon Kagaku Kaishi, Vol. 1993, No. 5, 1993, p. 411-417.

Research output: Contribution to journalArticle

Komiyama, Makoto ; Yashiro, Morio ; Matsumoto, Yoichi ; Sumaoka, Jun ; Matsumura, Kazunari. / Lanthanide Metal (III) Ions for Remarkably Efficient Hydrolyses of Phosphodiester Linkages in Biomaterials. In: Nippon Kagaku Kaishi. 1993 ; Vol. 1993, No. 5. pp. 411-417.
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AU - Sumaoka, Jun

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AB - Lanthanide metal(IH) ions remarkably catalyze the hydrolysis of phosphodiester linkages in DNA, RNA, and adenosine 3′, 5′-cyclic phosphate. The magnitudes of acceleration range from 104 to 1012 fold. With the use of Ce(III) ion (0. 01 mol-dm-3), the phosphodiester linkages in linear DNAs are hydrolyzed for the first time nonenzymatically (half-life 3. 6 h at pH 7. 2, 50°C). Furthermore, the linkages in both RNA and adenosine 3′, 5′-cyclic phosphate are efficiently hydrolyzed at pH 8.0, 30°C with the half-lives 10 min (by Tm(I)) and 36 \ seconds (by Ce(III)), respectively. Non-lanthanide metal ions show virtually no catalysis : the superb catalysis is specific for lanthanide metal ions. These results indicate high potentialities of the metal ions as the catalytic centers for the artificial enzymes which are applicable to regulation of various bio-reactions.

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