Light-drive biomedical micro tools and biochemical IC chips fabricated by 3D micro/nano stereolithography

Koji Ikuta; Shoji Maruo; Tadahiro Hasegawa; Suenobu Itho; Hayato Korogi; Atsushi Takahashi

doi:10.1117/12.581900

Light-drive biomedical micro tools and biochemical IC chips fabricated by 3D micro/nano stereolithography

Koji Ikuta, Shoji Maruo, Tadahiro Hasegawa, Suenobu Itho, Hayato Korogi, Atsushi Takahashi

Research output: Contribution to journal › Conference article › peer-review

5 Citations (Scopus)

Abstract

New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named "micro/nano stereolithography "has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional "lab. on a chip" and "micro total analysis system (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for "on chip cell-free protein synthesis" has been prototyped and verified experimentally. A luminous enzyme of fire fly so called " Luciferase" and useful bio-marker protein "GFP" were synthesized successfully. According to above results, the biomchemical IC chips will be useful to "Order-made medicine" in near future.

Original language	English
Article number	08
Pages (from-to)	52-66
Number of pages	15
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5604
DOIs	https://doi.org/10.1117/12.581900
Publication status	Published - 2004 Dec 1
Externally published	Yes
Event	Optomechatronic Micro/Nano Components, Devices, and Systems - Philadelphia, PA, United States Duration: 2004 Oct 27 → 2004 Oct 28

Keywords

Biochemical IC
Light drive
Micro stereolithography
Nano manipulator
Optical drive

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.581900

Cite this

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title = "Light-drive biomedical micro tools and biochemical IC chips fabricated by 3D micro/nano stereolithography",

abstract = "New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named {"}micro/nano stereolithography {"}has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional {"}lab. on a chip{"} and {"}micro total analysis system (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for {"}on chip cell-free protein synthesis{"} has been prototyped and verified experimentally. A luminous enzyme of fire fly so called {"} Luciferase{"} and useful bio-marker protein {"}GFP{"} were synthesized successfully. According to above results, the biomchemical IC chips will be useful to {"}Order-made medicine{"} in near future.",

keywords = "Biochemical IC, Light drive, Micro stereolithography, Nano manipulator, Optical drive",

author = "Koji Ikuta and Shoji Maruo and Tadahiro Hasegawa and Suenobu Itho and Hayato Korogi and Atsushi Takahashi",

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AU - Ikuta, Koji

AU - Maruo, Shoji

AU - Hasegawa, Tadahiro

AU - Itho, Suenobu

AU - Korogi, Hayato

AU - Takahashi, Atsushi

PY - 2004/12/1

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N2 - New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named "micro/nano stereolithography "has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional "lab. on a chip" and "micro total analysis system (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for "on chip cell-free protein synthesis" has been prototyped and verified experimentally. A luminous enzyme of fire fly so called " Luciferase" and useful bio-marker protein "GFP" were synthesized successfully. According to above results, the biomchemical IC chips will be useful to "Order-made medicine" in near future.

AB - New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named "micro/nano stereolithography "has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional "lab. on a chip" and "micro total analysis system (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for "on chip cell-free protein synthesis" has been prototyped and verified experimentally. A luminous enzyme of fire fly so called " Luciferase" and useful bio-marker protein "GFP" were synthesized successfully. According to above results, the biomchemical IC chips will be useful to "Order-made medicine" in near future.

KW - Biochemical IC

KW - Light drive

KW - Micro stereolithography

KW - Nano manipulator

KW - Optical drive

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ER -

Light-drive biomedical micro tools and biochemical IC chips fabricated by 3D micro/nano stereolithography

Abstract

Keywords

ASJC Scopus subject areas

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