Liver fibrosis structure effects on viscoelasticity estimation using group shear wave speeds

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Viscoelasticity measurements can improve the accuracy of liver fibrosis diagnosis for chronic hepatitis. Methods to estimate tissue viscoelasticity using frequency characteristics of the shear wave phase velocity are common but not robust. Therefore, in recent years, a technique to estimate viscoelasticity from group speeds in displacement and particle velocity has been proposed as a robust method [1]. However, we earlier reported that the liver fibrotic structure can change the frequency characteristics of phase velocity [2]. Therefore, in this study, we evaluated the influence of the liver fibrosis structure on the estimation method using group shear wave speeds. We used the previously developed liver fibrosis progression model to investigate the effect of the fibrous structure. Shear wave propagation was simulated using this model. Viscoelasticity was estimated using lookup tables that represented the relation between group speeds in displacement and particle velocity and viscoelasticity. When a shear wave reflection component is present, a directional filter is required. The directional filter affects the group speeds of the shear wave. Therefore, we established lookup tables considering the characteristics of the directional filter. Using these tables, we performed viscoelasticity estimations on liver fibrosis models and corresponding uniform models. In the uniform models, the viscoelasticity was estimated correctly. However, in the liver fibrosis models, the Young's modulus was estimated to be smaller than the actual value, and the shear viscosity coefficient was estimated to be greater than the actual value with the difference from the actual value increasing as fibrosis progressed.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages419-422
Number of pages4
ISBN (Electronic)9781728145969
DOIs
Publication statusPublished - 2019 Oct
Externally publishedYes
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: 2019 Oct 62019 Oct 9

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/TerritoryUnited Kingdom
CityGlasgow
Period19/10/619/10/9

Keywords

  • Elastography
  • group velocity
  • liver fibrosis structure
  • Shear wave
  • viscoelasticity measurement

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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