Localization of γ-glutamyl transpeptidase in human sweat glands: An immunohistochemical study using a monoclonal antibody

K. Yasuda, M. Shiozawa, S. Yamashita, S. Aiso

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We studied the distribution of γ-glutamyl transpeptidase (γ-GT) by use of a monoclonal antibody (MAb) against human kidney γ-GT in human sweat glands. In the eccrine sweat gland, the enzyme was localized along the luminal membrane and small apocrine extrusions of the superficial cells of the secretory portion. The intercellular canaliculi between basal cells were occasionally immunoreactive. In the secretory portion of the apocrine gland, luminal membrane and apocrine extrusions of various sizes and stages at the apices of the secretory cells exhibited positive reactions. Immunoreaction was also seen in the Golgi area of the cuboidal secretory cells. No positive reaction was observed in the myoepithelial cells of either gland or in the excretory duct cells.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalJournal of Histochemistry and Cytochemistry
Issue number10
Publication statusPublished - 1990 Jan 1



  • Human sweat gland
  • Immunohistochemistry
  • Monoclonal antibody
  • γ-Glutamyl transpeptidase

ASJC Scopus subject areas

  • Anatomy
  • Histology

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