Localization of Gamma-Glutamyl Transpeptidase in the Proliferative State of Liver An Enzyme Histochemical and Immunohistochemical Study

Masahide Shiozawa, Sadakazu Aiso, Osamu Hoshiai, Hiromu Tahara, Shuji Yamashita, Kenjiro Yasuda

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5 Citations (Scopus)

Abstract

The appearance and distribution of 7-glutamyl transpetidase (7-GTP) in the proliferative state of the liver were investigated by the methods of enzyme histochemistry and immunohistochemistry with monoclonal antibodies which specifically react with a heavy subunit of 7-GTP. In the fatal and neonatal liver, a positive reaction was observed along the luminal border of the interlobular bile ducts and that of the bile canaliculi in zones 1 and 2 of Rappaport. On the other hand, after partial hepatectomy, 7-GTP was localized along the luminal border of the interlobular bile ducts and that of the bile canaliculi in zone 1 of Rappaport. Both the enzyme histochemical and immunohistochemical methods yielded almost the same results for the distribution of 7-GTP.

Original languageEnglish
Pages (from-to)209-221
Number of pages13
JournalOkajimas Folia Anatomica Japonica
Volume63
Issue number4
DOIs
Publication statusPublished - 1986 Jan 1
Externally publishedYes

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Keywords

  • Aging
  • Gamma-GTP
  • Hepatectomy
  • Histochemistry
  • Immunohistochemistry
  • Rat

ASJC Scopus subject areas

  • Anatomy

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