Magnetically driven micro-movable electrode for cell coupling

Y. Yamanishi, T. Kawahara, T. Iyanagi, M. Hagiwara, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We developed a novel method of cell coupling on a chip by using magnetically driven microtool (MMT). It is made of nickel and is used as an electrode as well as a cell pusher. The novelty of this device is the electrode itself whose tip part is supported by a spring and is positioned by external magnetic field. We propose a new cell coupling chip which provides larger coupling force of cells by using a physical motion of MMT. The operation of the microelectrode showed that the oocyte is deformed and the donor cell is successfully coupled physically with the oocyte. The contact area between the cells was increased, and which is good for consequent fusion process. The FEM analysis on the electric field density also showed that a high concentration between the membrane of oocyte and donor cell. The proposed method is suited for cell fusion on a chip, and will contribute to high throughput cell manipulation.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages905-907
Number of pages3
Publication statusPublished - 2010 Dec 1
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/10/310/10/7

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Keywords

  • Cell Coupling
  • Cell Manipulation
  • Magnetically Driven Microtool
  • Microelectrode

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Yamanishi, Y., Kawahara, T., Iyanagi, T., Hagiwara, M., & Arai, F. (2010). Magnetically driven micro-movable electrode for cell coupling. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 905-907). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 2).