Manganese in toenails is associated with hearing loss at high frequencies in humans

Nobutaka Ohgami, Xiang Li, Ichiro Yajima, Reina Oshino, Kyoko Ohgami, Yoko Kato, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

Original languageEnglish
Pages (from-to)533-539
Number of pages7
JournalBiomarkers
Volume23
Issue number6
DOIs
Publication statusPublished - 2018 Aug 18
Externally publishedYes

Fingerprint

Audition
Manganese
Biomarkers
Nails
Inductively coupled plasma
Mass spectrometers
Association reactions

Keywords

  • hearing loss
  • ICP-MS
  • inner ears
  • Manganese
  • toenails

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Manganese in toenails is associated with hearing loss at high frequencies in humans. / Ohgami, Nobutaka; Li, Xiang; Yajima, Ichiro; Oshino, Reina; Ohgami, Kyoko; Kato, Yoko; Ahsan, Nazmul; Akhand, Anwarul Azim; Kato, Masashi.

In: Biomarkers, Vol. 23, No. 6, 18.08.2018, p. 533-539.

Research output: Contribution to journalArticle

Ohgami, N, Li, X, Yajima, I, Oshino, R, Ohgami, K, Kato, Y, Ahsan, N, Akhand, AA & Kato, M 2018, 'Manganese in toenails is associated with hearing loss at high frequencies in humans', Biomarkers, vol. 23, no. 6, pp. 533-539. https://doi.org/10.1080/1354750X.2018.1458153
Ohgami, Nobutaka ; Li, Xiang ; Yajima, Ichiro ; Oshino, Reina ; Ohgami, Kyoko ; Kato, Yoko ; Ahsan, Nazmul ; Akhand, Anwarul Azim ; Kato, Masashi. / Manganese in toenails is associated with hearing loss at high frequencies in humans. In: Biomarkers. 2018 ; Vol. 23, No. 6. pp. 533-539.
@article{9c34e6dddf484d10b9ef2d5c503fe59c,
title = "Manganese in toenails is associated with hearing loss at high frequencies in humans",
abstract = "Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.",
keywords = "hearing loss, ICP-MS, inner ears, Manganese, toenails",
author = "Nobutaka Ohgami and Xiang Li and Ichiro Yajima and Reina Oshino and Kyoko Ohgami and Yoko Kato and Nazmul Ahsan and Akhand, {Anwarul Azim} and Masashi Kato",
year = "2018",
month = "8",
day = "18",
doi = "10.1080/1354750X.2018.1458153",
language = "English",
volume = "23",
pages = "533--539",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Manganese in toenails is associated with hearing loss at high frequencies in humans

AU - Ohgami, Nobutaka

AU - Li, Xiang

AU - Yajima, Ichiro

AU - Oshino, Reina

AU - Ohgami, Kyoko

AU - Kato, Yoko

AU - Ahsan, Nazmul

AU - Akhand, Anwarul Azim

AU - Kato, Masashi

PY - 2018/8/18

Y1 - 2018/8/18

N2 - Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

AB - Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

KW - hearing loss

KW - ICP-MS

KW - inner ears

KW - Manganese

KW - toenails

UR - http://www.scopus.com/inward/record.url?scp=85045135138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045135138&partnerID=8YFLogxK

U2 - 10.1080/1354750X.2018.1458153

DO - 10.1080/1354750X.2018.1458153

M3 - Article

C2 - 29619852

AN - SCOPUS:85045135138

VL - 23

SP - 533

EP - 539

JO - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 6

ER -