Manganese in toenails is associated with hearing loss at high frequencies in humans

Nobutaka Ohgami; Xiang Li; Ichiro Yajima; Reina Oshino; Kyoko Ohgami; Yoko Kato; Nazmul Ahsan; Anwarul Azim Akhand; Masashi Kato

doi:10.1080/1354750X.2018.1458153

Manganese in toenails is associated with hearing loss at high frequencies in humans

Nobutaka Ohgami, Xiang Li, Ichiro Yajima, Reina Oshino, Kyoko Ohgami, Yoko Kato, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

Original language	English
Pages (from-to)	533-539
Number of pages	7
Journal	Biomarkers
Volume	23
Issue number	6
DOIs	https://doi.org/10.1080/1354750X.2018.1458153
Publication status	Published - 2018 Aug 18
Externally published	Yes

Keywords

ICP-MS
Manganese
hearing loss
inner ears
toenails

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.1080/1354750X.2018.1458153

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@article{9c34e6dddf484d10b9ef2d5c503fe59c,

title = "Manganese in toenails is associated with hearing loss at high frequencies in humans",

abstract = "Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.",

keywords = "ICP-MS, Manganese, hearing loss, inner ears, toenails",

author = "Nobutaka Ohgami and Xiang Li and Ichiro Yajima and Reina Oshino and Kyoko Ohgami and Yoko Kato and Nazmul Ahsan and Akhand, {Anwarul Azim} and Masashi Kato",

note = "Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research on Innovative Areas (24108001 and 16H01639), Scientific Research (A) (15H01743 and 15H02588), (B) (16H02962, 17KT0033) and (C) (16K08343) and Grant-in-Aid for Challenging Exploratory Research (26670525) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Japan Health Foundation, the Mitsui & Co., Ltd. Environment Fund, Foundation from Center for Advanced Medical and Clinical Research Nagoya University Hospital, the Mitsubishi Foundation, AEON Environmental Foundation, Nagono Medical Foundation, The Salt Science Research Foundation and Grant for Environmental Research Projects from the Sumitomo Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

month = aug,

day = "18",

doi = "10.1080/1354750X.2018.1458153",

language = "English",

volume = "23",

pages = "533--539",

journal = "Biomarkers",

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number = "6",

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TY - JOUR

T1 - Manganese in toenails is associated with hearing loss at high frequencies in humans

AU - Ohgami, Nobutaka

AU - Li, Xiang

AU - Yajima, Ichiro

AU - Oshino, Reina

AU - Ohgami, Kyoko

AU - Kato, Yoko

AU - Ahsan, Nazmul

AU - Akhand, Anwarul Azim

AU - Kato, Masashi

N1 - Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research on Innovative Areas (24108001 and 16H01639), Scientific Research (A) (15H01743 and 15H02588), (B) (16H02962, 17KT0033) and (C) (16K08343) and Grant-in-Aid for Challenging Exploratory Research (26670525) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Japan Health Foundation, the Mitsui & Co., Ltd. Environment Fund, Foundation from Center for Advanced Medical and Clinical Research Nagoya University Hospital, the Mitsubishi Foundation, AEON Environmental Foundation, Nagono Medical Foundation, The Salt Science Research Foundation and Grant for Environmental Research Projects from the Sumitomo Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2018/8/18

Y1 - 2018/8/18

N2 - Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

AB - Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.

KW - ICP-MS

KW - Manganese

KW - hearing loss

KW - inner ears

KW - toenails

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DO - 10.1080/1354750X.2018.1458153

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C2 - 29619852

AN - SCOPUS:85045135138

SN - 1354-750X

VL - 23

SP - 533

EP - 539

JO - Biomarkers

JF - Biomarkers

IS - 6

ER -

Manganese in toenails is associated with hearing loss at high frequencies in humans

Abstract

Keywords

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