Manganese-mediated acceleration of age-related hearing loss in mice

Nobutaka Ohgami, Ichiro Yajima, Machiko Iida, Xiang Li, Reina Oshino, Mayuko Y. Kumasaka, Masashi Kato

Research output: Contribution to journalArticle

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Abstract

Despite the fact that manganese (Mn) is known to be a neurotoxic element relevant to age-related disorders, the risk of oral exposure to Mn for age-related hearing loss remains unclear. In this study, we orally exposed wild-type young adult mice to Mn (Mn-exposed WT-mice) at 1.65 and 16.50 mg/L for 4 weeks. Mn-exposed WT-mice showed acceleration of age-related hearing loss. Mn-exposed WT-mice had neurodegeneration of spiral ganglion neurons (SGNs) with increased number of lipofuscin granules. Mn-exposed WT-mice also had increased hypoxia-inducible factor-1 alpha (Hif-1α) protein with less hydroxylation at proline 564 and decreased c-Ret protein in SGNs. Mn-mediated acceleration of age-related hearing loss involving neurodegeneration of SGNs was rescued in RET-transgenic mice carrying constitutively activated RET. Thus, oral exposure to Mn accelerates age-related hearing loss in mice with Ret-mediated neurodegeneration of SGNs.

Original languageEnglish
Article number36306
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Nov 8
Externally publishedYes

ASJC Scopus subject areas

  • General

Cite this

Ohgami, N., Yajima, I., Iida, M., Li, X., Oshino, R., Kumasaka, M. Y., & Kato, M. (2016). Manganese-mediated acceleration of age-related hearing loss in mice. Scientific Reports, 6, [36306]. https://doi.org/10.1038/srep36306

Manganese-mediated acceleration of age-related hearing loss in mice. / Ohgami, Nobutaka; Yajima, Ichiro; Iida, Machiko; Li, Xiang; Oshino, Reina; Kumasaka, Mayuko Y.; Kato, Masashi.

In: Scientific Reports, Vol. 6, 36306, 08.11.2016.

Research output: Contribution to journalArticle

Ohgami, N, Yajima, I, Iida, M, Li, X, Oshino, R, Kumasaka, MY & Kato, M 2016, 'Manganese-mediated acceleration of age-related hearing loss in mice', Scientific Reports, vol. 6, 36306. https://doi.org/10.1038/srep36306
Ohgami, Nobutaka ; Yajima, Ichiro ; Iida, Machiko ; Li, Xiang ; Oshino, Reina ; Kumasaka, Mayuko Y. ; Kato, Masashi. / Manganese-mediated acceleration of age-related hearing loss in mice. In: Scientific Reports. 2016 ; Vol. 6.
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