TY - JOUR
T1 - Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization
AU - Ibrahim, Mohd Danial
AU - Yunos, Yana Shaheera
AU - Watanabe, Nobuo
AU - Mohtadzar, Nur Alia Athirah
AU - Semait, Siti Noor Haizum
AU - Rigit, Andrew Ragai Henry
AU - Sunami, Yuta
AU - Wong, Lee Kwang
AU - Rahman, Mohd Rahmat A.
AU - Mohtar, Muhammad Zaidi
N1 - Funding Information:
The present work was partially funded by Fundamental Research Grant Scheme, Ministry of Education Malaysia, Grant No: FRGS/TK01 (01)/1059/2013(05) and UNIMAS Special Short Term Grant, Grant No: F02/SpSTG/1386/16/28. The authors also declares that there is no conflict of interest regarding the publication of this paper.
Publisher Copyright:
© 2017, Chulalongkorn University 1. All rights reserved.
PY - 2017/7/31
Y1 - 2017/7/31
N2 - This paper presents micro-needle with different tip and inner structure of the needle for optimizations of pain stresses and drug or blood deliveries. The micro-needle comes with several design’s parameters of length ranging from 5mm to 50mm and diameter ranging from 100μm to 200μm. A hollow micro-needle with four different tip designs which are 10°, D3-2, D6 and Quadruple are also designed to optimize the pain stresses parameters. In order to improve the flow deliveries, the inner structure of the channel is modified into various polygonal shape which is square, hexagon and dodecagon. It shows that, having less contact surface area between the skin and micro-needle’s tip and polygonal shape of inner channel has better performance for both of the objectives. These feasible region of average velocity and stress of the micro-needle have satisfied in determining the best design for tip and inner channel of the micro-needle under certain conditions and constraints. The three-dimensional geometry study had improved the insertions performance and efficiencies in painless drug or blood deliveries.
AB - This paper presents micro-needle with different tip and inner structure of the needle for optimizations of pain stresses and drug or blood deliveries. The micro-needle comes with several design’s parameters of length ranging from 5mm to 50mm and diameter ranging from 100μm to 200μm. A hollow micro-needle with four different tip designs which are 10°, D3-2, D6 and Quadruple are also designed to optimize the pain stresses parameters. In order to improve the flow deliveries, the inner structure of the channel is modified into various polygonal shape which is square, hexagon and dodecagon. It shows that, having less contact surface area between the skin and micro-needle’s tip and polygonal shape of inner channel has better performance for both of the objectives. These feasible region of average velocity and stress of the micro-needle have satisfied in determining the best design for tip and inner channel of the micro-needle under certain conditions and constraints. The three-dimensional geometry study had improved the insertions performance and efficiencies in painless drug or blood deliveries.
KW - Blood delivery
KW - Drug delivery
KW - Micro-needle
KW - Polygonal micro-needle
KW - Quadrupletip micro-needle
UR - http://www.scopus.com/inward/record.url?scp=85027709505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027709505&partnerID=8YFLogxK
U2 - 10.4186/ej.2017.21.4.207
DO - 10.4186/ej.2017.21.4.207
M3 - Article
AN - SCOPUS:85027709505
SN - 0125-8281
VL - 21
SP - 207
EP - 216
JO - Engineering Journal
JF - Engineering Journal
IS - 4
ER -