Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization

Mohd Danial Ibrahim, Yana Shaheera Yunos, Nobuo Watanabe, Nur Alia Athirah Mohtadzar, Siti Noor Haizum Semait, Andrew Ragai Henry Rigit, Yuta Sunami, Lee Kwang Wong, Mohd Rahmat A. Rahman, Muhammad Zaidi Mohtar

Research output: Research - peer-reviewArticle

Abstract

This paper presents micro-needle with different tip and inner structure of the needle for optimizations of pain stresses and drug or blood deliveries. The micro-needle comes with several design’s parameters of length ranging from 5mm to 50mm and diameter ranging from 100μm to 200μm. A hollow micro-needle with four different tip designs which are 10°, D3-2, D6 and Quadruple are also designed to optimize the pain stresses parameters. In order to improve the flow deliveries, the inner structure of the channel is modified into various polygonal shape which is square, hexagon and dodecagon. It shows that, having less contact surface area between the skin and micro-needle’s tip and polygonal shape of inner channel has better performance for both of the objectives. These feasible region of average velocity and stress of the micro-needle have satisfied in determining the best design for tip and inner channel of the micro-needle under certain conditions and constraints. The three-dimensional geometry study had improved the insertions performance and efficiencies in painless drug or blood deliveries.

LanguageEnglish
Pages207-216
Number of pages10
JournalEngineering Journal
Volume21
Issue number4
DOIs
StatePublished - 2017 Jul 31

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Needles
Blood
Skin
Geometry

Keywords

  • Blood delivery
  • Drug delivery
  • Micro-needle
  • Polygonal micro-needle
  • Quadrupletip micro-needle

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ibrahim, M. D., Yunos, Y. S., Watanabe, N., Mohtadzar, N. A. A., Semait, S. N. H., Rigit, A. R. H., ... Mohtar, M. Z. (2017). Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization. Engineering Journal, 21(4), 207-216. DOI: 10.4186/ej.2017.21.4.207

Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization. / Ibrahim, Mohd Danial; Yunos, Yana Shaheera; Watanabe, Nobuo; Mohtadzar, Nur Alia Athirah; Semait, Siti Noor Haizum; Rigit, Andrew Ragai Henry; Sunami, Yuta; Wong, Lee Kwang; Rahman, Mohd Rahmat A.; Mohtar, Muhammad Zaidi.

In: Engineering Journal, Vol. 21, No. 4, 31.07.2017, p. 207-216.

Research output: Research - peer-reviewArticle

Ibrahim, MD, Yunos, YS, Watanabe, N, Mohtadzar, NAA, Semait, SNH, Rigit, ARH, Sunami, Y, Wong, LK, Rahman, MRA & Mohtar, MZ 2017, 'Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization' Engineering Journal, vol 21, no. 4, pp. 207-216. DOI: 10.4186/ej.2017.21.4.207
Ibrahim MD, Yunos YS, Watanabe N, Mohtadzar NAA, Semait SNH, Rigit ARH et al. Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization. Engineering Journal. 2017 Jul 31;21(4):207-216. Available from, DOI: 10.4186/ej.2017.21.4.207
Ibrahim, Mohd Danial ; Yunos, Yana Shaheera ; Watanabe, Nobuo ; Mohtadzar, Nur Alia Athirah ; Semait, Siti Noor Haizum ; Rigit, Andrew Ragai Henry ; Sunami, Yuta ; Wong, Lee Kwang ; Rahman, Mohd Rahmat A. ; Mohtar, Muhammad Zaidi. / Micro-needle with polygonal structure of micro-channel for stress and blood or drug flow optimization. In: Engineering Journal. 2017 ; Vol. 21, No. 4. pp. 207-216
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