Microfluidic analysis of pressure drop and flow behavior in hypertensive micro vessels

Ruiqing Hu, Fen Li, Jiaqi Lv, Ying He, Detang Lu, Takashi Yamada, Naoki Ono

Research output: Research - peer-reviewArticle

  • 2 Citations

Abstract

The retinal arterial network is the only source of the highly nutrient-consumptive retina, thus any insult on the arteries can impair the retinal oxygen and nutrient supply and affect its normal function. The aim of this work is to study the influences of vascular structure variation on the flow and pressure characteristics via microfluidic devices. Two sets of micro-channel were designed to mimic the stenosed microvessels and dichotomous branching structure in the retinal arteries. Three working fluids including red blood cell (RBC) suspension were employed to investigate the pressure drop in the stenosed channel. The flow behaviors of RBC suspensions inside the micro channels were observed using high speed camera system. Pressure drop of different working fluids and RBC velocity profiles in the stenosed channel were obtained. Moreover, hematocrit levels of RBC suspensions inside the bifurcated channels were analyzed from the sequential images of RBC flow. The results of the flow in the stenosed channel show that RBCs drift from the center of the channels, and RBC velocity is influenced not only by the inlet flow rate but also the interaction between RBCs. The measured pressure drops in the stenosed channel increase notably with the increase of fluid viscosity. Furthermore, the dimensionless pressure drop due to the stenosis decreases with Reynolds number. On the other hand, the results of flow through the bifurcated channels show that as the ratio of the daughter-branch width to the mother-channel width increases, the ratio of hematocrit in two connected branches (Ht/Hd) decreases, which is in favorable agreement with the available analysis results.

LanguageEnglish
Article number60
Pages1-9
Number of pages9
JournalBiomedical Microdevices
Volume17
Issue number3
DOIs
StatePublished - 2015 Jun 1

Fingerprint

Microfluidics
Pressure drop
Blood
Fluids
Nutrients
Cells
Inlet flow
High speed cameras
Reynolds number
Flow rate
Viscosity
Oxygen

Keywords

  • Fahreaus effect
  • Hematocrit
  • Microfluidic device
  • Pressure drop
  • RBC velocity

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

Cite this

Microfluidic analysis of pressure drop and flow behavior in hypertensive micro vessels. / Hu, Ruiqing; Li, Fen; Lv, Jiaqi; He, Ying; Lu, Detang; Yamada, Takashi; Ono, Naoki.

In: Biomedical Microdevices, Vol. 17, No. 3, 60, 01.06.2015, p. 1-9.

Research output: Research - peer-reviewArticle

Hu R, Li F, Lv J, He Y, Lu D, Yamada T et al. Microfluidic analysis of pressure drop and flow behavior in hypertensive micro vessels. Biomedical Microdevices. 2015 Jun 1;17(3):1-9. 60. Available from, DOI: 10.1007/s10544-015-9959-4
Hu, Ruiqing ; Li, Fen ; Lv, Jiaqi ; He, Ying ; Lu, Detang ; Yamada, Takashi ; Ono, Naoki. / Microfluidic analysis of pressure drop and flow behavior in hypertensive micro vessels. In: Biomedical Microdevices. 2015 ; Vol. 17, No. 3. pp. 1-9
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