Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave

Atsushi Takano, Tasuku Kon, Yasubumi Furuya, Katsumi Mochitate, Masato Tanaka, Nobuyuki Futai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).

Original languageEnglish
Title of host publication2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PublisherIEEE Computer Society
ISBN (Print)9781479915293
DOIs
Publication statusPublished - 2013 Jan 1
Event2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan
Duration: 2013 Nov 102013 Nov 13

Publication series

Name2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013

Conference

Conference2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
CountryJapan
CityNagoya
Period13/11/1013/11/13

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Takano, A., Kon, T., Furuya, Y., Mochitate, K., Tanaka, M., & Futai, N. (2013). Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 [6710472] (2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013). IEEE Computer Society. https://doi.org/10.1109/MHS.2013.6710472