Microfluidic model of bubble lodging in microvessel bifurcations

Andŕs J. Calderón, Yun Seok Heo, Dongeun Huh, Nobuyuki Futai, Shuichi Takayama, J. Brian Fowlkes, Joseph L. Bull

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

Original languageEnglish
Article number244103
JournalApplied Physics Letters
Volume89
Issue number24
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

bubbles
tumors
gases
infarction
critical pressure
blood flow
vessels
cancer
estimates

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Calderón, A. J., Heo, Y. S., Huh, D., Futai, N., Takayama, S., Fowlkes, J. B., & Bull, J. L. (2006). Microfluidic model of bubble lodging in microvessel bifurcations. Applied Physics Letters, 89(24), [244103]. https://doi.org/10.1063/1.2402898

Microfluidic model of bubble lodging in microvessel bifurcations. / Calderón, Andŕs J.; Heo, Yun Seok; Huh, Dongeun; Futai, Nobuyuki; Takayama, Shuichi; Fowlkes, J. Brian; Bull, Joseph L.

In: Applied Physics Letters, Vol. 89, No. 24, 244103, 2006.

Research output: Contribution to journalArticle

Calderón, AJ, Heo, YS, Huh, D, Futai, N, Takayama, S, Fowlkes, JB & Bull, JL 2006, 'Microfluidic model of bubble lodging in microvessel bifurcations', Applied Physics Letters, vol. 89, no. 24, 244103. https://doi.org/10.1063/1.2402898
Calderón, Andŕs J. ; Heo, Yun Seok ; Huh, Dongeun ; Futai, Nobuyuki ; Takayama, Shuichi ; Fowlkes, J. Brian ; Bull, Joseph L. / Microfluidic model of bubble lodging in microvessel bifurcations. In: Applied Physics Letters. 2006 ; Vol. 89, No. 24.
@article{0e190c10d6af4df69d3b62f550c4525c,
title = "Microfluidic model of bubble lodging in microvessel bifurcations",
abstract = "The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.",
author = "Calder{\'o}n, {Andŕs J.} and Heo, {Yun Seok} and Dongeun Huh and Nobuyuki Futai and Shuichi Takayama and Fowlkes, {J. Brian} and Bull, {Joseph L.}",
year = "2006",
doi = "10.1063/1.2402898",
language = "English",
volume = "89",
journal = "Applied Physics Letters",
issn = "0003-6951",
publisher = "American Institute of Physics Publising LLC",
number = "24",

}

TY - JOUR

T1 - Microfluidic model of bubble lodging in microvessel bifurcations

AU - Calderón, Andŕs J.

AU - Heo, Yun Seok

AU - Huh, Dongeun

AU - Futai, Nobuyuki

AU - Takayama, Shuichi

AU - Fowlkes, J. Brian

AU - Bull, Joseph L.

PY - 2006

Y1 - 2006

N2 - The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

AB - The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

UR - http://www.scopus.com/inward/record.url?scp=33845772863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845772863&partnerID=8YFLogxK

U2 - 10.1063/1.2402898

DO - 10.1063/1.2402898

M3 - Article

VL - 89

JO - Applied Physics Letters

JF - Applied Physics Letters

SN - 0003-6951

IS - 24

M1 - 244103

ER -