Microfluidic model of bubble lodging in microvessel bifurcations

Andŕs J. Calderón, Yun Seok Heo, Dongeun Huh, Nobuyuki Futai, Shuichi Takayama, J. Brian Fowlkes, Joseph L. Bull

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35 Citations (Scopus)

Abstract

The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

Original languageEnglish
Article number244103
JournalApplied Physics Letters
Volume89
Issue number24
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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    Calderón, A. J., Heo, Y. S., Huh, D., Futai, N., Takayama, S., Fowlkes, J. B., & Bull, J. L. (2006). Microfluidic model of bubble lodging in microvessel bifurcations. Applied Physics Letters, 89(24), [244103]. https://doi.org/10.1063/1.2402898