TY - GEN
T1 - Microscopic measurement of three-dimensional distribution of tissue viscoelasticity
AU - Shiina, Tsuyoshi
AU - Yoshida, Masashi
AU - Yamakawa, Makoto
AU - Nitta, Naotaka
PY - 2007
Y1 - 2007
N2 - Elasticity imaging system development has recently yielded practical systems that can be applied in clinical use. To diagnosis disease progression and precisely differentiate tissue types in elasticity images, we must first clarify the quantitative relationship between tissue viscoelasticity and diseases. However, no database for such a relationship has been yet established. From this viewpoint, we are investigating a three-dimensional tissue viscoelasticity microscope for accumulating quantitative data on tissue mechanical properties. We considered measuring the relatively thick tissue samples in order to preserve the microstructure of tissues and thus to avoid changes of tissue mechanical properties. Our proposed microscopic measurement is based on static methods and obtains Young' s modulus and hysteresis parameter (HP) as viscoelastic properties of tissues. Results of simulation analysis and experiments demonstrated that our basic system could acquire the three-dimensional distributions of the elastic modulus and HP with reasonable resolution and precision.
AB - Elasticity imaging system development has recently yielded practical systems that can be applied in clinical use. To diagnosis disease progression and precisely differentiate tissue types in elasticity images, we must first clarify the quantitative relationship between tissue viscoelasticity and diseases. However, no database for such a relationship has been yet established. From this viewpoint, we are investigating a three-dimensional tissue viscoelasticity microscope for accumulating quantitative data on tissue mechanical properties. We considered measuring the relatively thick tissue samples in order to preserve the microstructure of tissues and thus to avoid changes of tissue mechanical properties. Our proposed microscopic measurement is based on static methods and obtains Young' s modulus and hysteresis parameter (HP) as viscoelastic properties of tissues. Results of simulation analysis and experiments demonstrated that our basic system could acquire the three-dimensional distributions of the elastic modulus and HP with reasonable resolution and precision.
KW - Elastic modulus
KW - Tissue characterization
KW - Ultrasound microscope
KW - Viscoelasticity
UR - http://www.scopus.com/inward/record.url?scp=48149092423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48149092423&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2007.512
DO - 10.1109/ULTSYM.2007.512
M3 - Conference contribution
AN - SCOPUS:48149092423
SN - 1424413834
SN - 9781424413836
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 2036
EP - 2039
BT - 2007 IEEE Ultrasonics Symposium Proceedings, IUS
T2 - 2007 IEEE Ultrasonics Symposium, IUS
Y2 - 28 October 2007 through 31 October 2007
ER -