Microscopic measurement of three-dimensional distribution of tissue viscoelasticity

Tsuyoshi Shiina, Masashi Yoshida, Makoto Yamakawa, Naotaka Nitta

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Elasticity imaging system development has recently yielded practical systems that can be applied in clinical use. To diagnosis disease progression and precisely differentiate tissue types in elasticity images, we must first clarify the quantitative relationship between tissue viscoelasticity and diseases. However, no database for such a relationship has been yet established. From this viewpoint, we are investigating a three-dimensional tissue viscoelasticity microscope for accumulating quantitative data on tissue mechanical properties. We considered measuring the relatively thick tissue samples in order to preserve the microstructure of tissues and thus to avoid changes of tissue mechanical properties. Our proposed microscopic measurement is based on static methods and obtains Young' s modulus and hysteresis parameter (HP) as viscoelastic properties of tissues. Results of simulation analysis and experiments demonstrated that our basic system could acquire the three-dimensional distributions of the elastic modulus and HP with reasonable resolution and precision.

Original languageEnglish
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings, IUS
Number of pages4
Publication statusPublished - 2007
Externally publishedYes
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: 2007 Oct 282007 Oct 31

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Conference2007 IEEE Ultrasonics Symposium, IUS
Country/TerritoryUnited States
CityNew York, NY


  • Elastic modulus
  • Tissue characterization
  • Ultrasound microscope
  • Viscoelasticity

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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