Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor

Takahiro Arakawa, Yusuke Kuroki, Hiroki Nitta, Prem Chouhan, Koji Toma, Shin ichi Sawada, Shuhei Takeuchi, Toshiaki Sekita, Kazunari Akiyoshi, Shunsuke Minakuchi, Kohji Mitsubayashi

Research output: Contribution to journalArticlepeer-review

170 Citations (Scopus)

Abstract

We develop detachable “Cavitas sensors” to apply to the human oral cavity for non-invasive monitoring of saliva glucose. A salivary biosensor incorporating Pt and Ag/AgCl electrodes on a mouthguard support with an enzyme membrane is developed and tested. Electrodes are formed on the polyethylene terephthalate glycol (PETG) surface of the mouthguard. The Pt working electrode is coated with a glucose oxidase (GOD) membrane. The biosensor seamlessly is integrated with a glucose sensor and a wireless measurement system. When investigating in-vitro performance, the biosensor exhibits a robust relationship between output current and glucose concentration. In artificial saliva composed of salts and proteins, the glucose sensor is capable of highly sensitive detection over a range of 5–1000 µmol/L of glucose, which encompasses the range of glucose concentrations found in human saliva. We demonstrate the ability of the sensor and wireless communication module to monitor saliva glucose in a phantom jaw imitating the structure of the human oral cavity. Stable and long-term real-time monitoring (exceeding 5 h) with the telemetry system is achieved. The mouthguard biosensor will be useful as a novel method for real-time non-invasive saliva glucose monitoring for better management of dental patients.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalBiosensors and Bioelectronics
Volume84
DOIs
Publication statusPublished - 2016 Oct 1
Externally publishedYes

Keywords

  • Biosensor
  • Glucose
  • Glucose oxidase
  • Mouthguard
  • Oral cavity
  • Saliva glucose

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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