Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Masashi Kato, Nobutaka Ohgami, Shoko Ohnuma, Kazunori Hashimoto, Akira Tazaki, Huadong Xu, Lisa Kondo-Ida, Tian Yuan, Tomoyuki Tsuchiyama, Tingchao He, Fitri Kurniasari, Yishuo Gu, Wei Chen, Yuqi Deng, Kanako Komuro, Keming Tong, Ichiro Yajima

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.

Original languageEnglish
Article number02000855
JournalEnvironmental Health and Preventive Medicine
Issue number1
Publication statusPublished - 2020 May 27
Externally publishedYes


  • Arsenic
  • Barium
  • Comprehensive study
  • Drinking water
  • Remediation
  • Toxic elements

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water'. Together they form a unique fingerprint.

Cite this