Neuroprotection against neurodegenerative diseases: Development of a novel hybrid neuroprotective peptide Colivelin

Tomohiro Chiba, Ikuo Nishimoto, Sadakazu Aiso, Masaaki Matsuoka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Neuronal death is directly implicated in the pathogenesis of neurodegenerative diseases (NDDs). NDDs cannot be cured because the mechanisms underlying neuronal death are too complicated to be therapeutically suppressed. Neuroprotective factors, such as neurotrophins, certain growth factors, neurotrophic cytokines, and short neuroprotective peptides, support neuronal survival in both physiological and pathological conditions, suggesting that these factors may be good drug candidates for NDDs. We recently generated a novel neuroprotective peptide named Colivelin by attaching activity-dependent neurotrophic factor (ADNF) to the N-terminus of a potent Humanin derivative, AGA-(C8R)HNG17. HN was originally identified from an Alzheimer's disease (AD) brain as an endogenous neuroprotective peptide that suppresses ADrelevant toxicity. Colivelin protects neurons from death relevant to NDDs by activating two independent prosurvival signals: an ADNF-mediated Ca2+/calmodulin-dependent protein kinase IV pathway and an HN-mediated STAT3 pathway. The neuroprotective effect of Colivelin provides novel insights into therapy for NDDs.

Original languageEnglish
Pages (from-to)55-84
Number of pages30
JournalMolecular Neurobiology
Volume35
Issue number1
DOIs
Publication statusPublished - 2007 Feb

Keywords

  • ADNF
  • Colivelin
  • Humanin
  • Neurodegenerative diseases
  • Neuronal death
  • Neuroprotection

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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