New feature for histopathologic diagnosis of early hepatocellular carcinoma - Degree of nuclear concentration -

Y. Tanimoto, M. Takahashi, K. Oguruma, M. Nakano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the field of histopathologic diagnosis, differential diagnosis of borderline lesions is a serious problem. Especially, differential diagnosis between early welldifferentiated hepatocellular carcinoma (ewHCC) and noncancer is difficult because the cellular atypism of ewHCC is very low. Nuclear density (number of nuclei per unit area) is one of features effective to diagnose ewHCC. In this paper, we propose new feature, degree of nuclear concentration, which represents the degree how densely nuclei are locally distributed. Two methods, counting method and density method, are proposed to quantify this feature. Counting method detects the dense regions, the regions where nuclei are densely distributed, by counting the number of nuclei in a circle. Density method converts each nuclear position to density distribution, and detects the dense regions as the regions having high density value. About 90% of correct ratio was obtained for both methods by the experiment, which shows effectiveness of this new feature. The feature was effective even if the nuclear density was normalized. Relative index, the ratio of features between ewHCC and non-cancer, was also shown to become another effective feature.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Pages1083-1086
Number of pages4
Edition4
DOIs
Publication statusPublished - 2009 Dec 1
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: 2009 Sep 72009 Sep 12

Publication series

NameIFMBE Proceedings
Number4
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period09/9/709/9/12

Keywords

  • Density
  • Hepatocellular carcinoma
  • Histopathology
  • Nuclear concentration
  • Nucleus

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'New feature for histopathologic diagnosis of early hepatocellular carcinoma - Degree of nuclear concentration -'. Together they form a unique fingerprint.

  • Cite this

    Tanimoto, Y., Takahashi, M., Oguruma, K., & Nakano, M. (2009). New feature for histopathologic diagnosis of early hepatocellular carcinoma - Degree of nuclear concentration -. In World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics (4 ed., pp. 1083-1086). (IFMBE Proceedings; Vol. 25, No. 4). https://doi.org/10.1007/978-3-642-03882-2-288