Nitric oxide contribution to vascular wall oxygen consumption in arterioles

Masahiro Shibata, T. Yamakoshi, K. Yamakoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured in vivo during flow-induced vasodilation and after inhibiting NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the intra- and peri-vascular oxygen tension (PO2) values measured by phosphorescence quenching laser microscopy. The peri-vascular PO2 value of the arterioles during vasodilation was significantly higher than under control conditions, although the intravascular PO2 values under both conditions were approximately the same. On the other hand, inhibition of NO synthesis caused a significant decrease in both the intra- and peri-vascular PO2 values of the arterioles. The inhibition of NO synthesis increased the oxygen consumption rate of the vessel walls by 42%, whereas enhancement of flow-induced NO release decreased it by 34%. These results suggest that NO plays an important role not only as a regulator of peripheral vascular tone, but also as a modulator of tissue oxygen consumption by reducing oxygen consumption by vessel walls.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages6703-6706
Number of pages4
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY
Duration: 2006 Aug 302006 Sep 3

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CityNew York, NY
Period06/8/3006/9/3

Fingerprint

Nitric oxide
Nitric Oxide
Oxygen
Phosphorescence
Modulators
Muscle
Rats
Quenching
Microscopic examination
Tissue
Lasers

ASJC Scopus subject areas

  • Bioengineering

Cite this

Shibata, M., Yamakoshi, T., & Yamakoshi, K. (2006). Nitric oxide contribution to vascular wall oxygen consumption in arterioles. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 6703-6706). [4030637] https://doi.org/10.1109/IEMBS.2006.260926

Nitric oxide contribution to vascular wall oxygen consumption in arterioles. / Shibata, Masahiro; Yamakoshi, T.; Yamakoshi, K.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6703-6706 4030637.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shibata, M, Yamakoshi, T & Yamakoshi, K 2006, Nitric oxide contribution to vascular wall oxygen consumption in arterioles. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4030637, pp. 6703-6706, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, 06/8/30. https://doi.org/10.1109/IEMBS.2006.260926
Shibata M, Yamakoshi T, Yamakoshi K. Nitric oxide contribution to vascular wall oxygen consumption in arterioles. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6703-6706. 4030637 https://doi.org/10.1109/IEMBS.2006.260926
Shibata, Masahiro ; Yamakoshi, T. ; Yamakoshi, K. / Nitric oxide contribution to vascular wall oxygen consumption in arterioles. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 6703-6706
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