Non-invasive evaluation of hepatic fibrosis for type c chronic hepatitis

Chie Tatsumi; Masatoshi Kudo; Kazuomi Ueshima; Satoshi Kitai; Emi Ishikawa; Norihisa Yada; Satoru Hagiwara; Tatsuo Inoue; Yasunori Minami; Hobyung Chung; Kiyoshi Maekawa; Kenji Fujimoto; Michio Kato; Akiko Tonomura; Tsuyoshi Mitake; Tsuyoshi Shiina

doi:10.1159/000252789

Non-invasive evaluation of hepatic fibrosis for type c chronic hepatitis

Chie Tatsumi, Masatoshi Kudo, Kazuomi Ueshima, Satoshi Kitai, Emi Ishikawa, Norihisa Yada, Satoru Hagiwara, Tatsuo Inoue, Yasunori Minami, Hobyung Chung, Kiyoshi Maekawa, Kenji Fujimoto, Michio Kato, Akiko Tonomura, Tsuyoshi Mitake, Tsuyoshi Shiina

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

Original language	English
Pages (from-to)	76-81
Number of pages	6
Journal	Intervirology
Volume	53
Issue number	1
DOIs	https://doi.org/10.1159/000252789
Publication status	Published - 2010 Jan
Externally published	Yes

Keywords

Biopsy, liver
FibroScan
Fibrosis, liver
Real-time tissue elastography

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1159/000252789

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title = "Non-invasive evaluation of hepatic fibrosis for type c chronic hepatitis",

abstract = "Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography{\textregistered} (RTE) and transient elastography (FibroScan{\textregistered}) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.",

keywords = "Biopsy, liver, FibroScan, Fibrosis, liver, Real-time tissue elastography",

author = "Chie Tatsumi and Masatoshi Kudo and Kazuomi Ueshima and Satoshi Kitai and Emi Ishikawa and Norihisa Yada and Satoru Hagiwara and Tatsuo Inoue and Yasunori Minami and Hobyung Chung and Kiyoshi Maekawa and Kenji Fujimoto and Michio Kato and Akiko Tonomura and Tsuyoshi Mitake and Tsuyoshi Shiina",

year = "2010",

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doi = "10.1159/000252789",

language = "English",

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T1 - Non-invasive evaluation of hepatic fibrosis for type c chronic hepatitis

AU - Tatsumi, Chie

AU - Kudo, Masatoshi

AU - Ueshima, Kazuomi

AU - Kitai, Satoshi

AU - Ishikawa, Emi

AU - Yada, Norihisa

AU - Hagiwara, Satoru

AU - Inoue, Tatsuo

AU - Minami, Yasunori

AU - Chung, Hobyung

AU - Maekawa, Kiyoshi

AU - Fujimoto, Kenji

AU - Kato, Michio

AU - Tonomura, Akiko

AU - Mitake, Tsuyoshi

AU - Shiina, Tsuyoshi

PY - 2010/1

Y1 - 2010/1

N2 - Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

AB - Objective: The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography® (RTE) and transient elastography (FibroScan®) methods. Methods: RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis. Results: FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed. Conclusion: FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.

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KW - FibroScan

KW - Fibrosis, liver

KW - Real-time tissue elastography

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Non-invasive evaluation of hepatic fibrosis for type c chronic hepatitis

Abstract

Keywords

ASJC Scopus subject areas

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