Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma

Yasuhiro Omata, Machiko Iida, Ichiro Yajima, Kozue Takeda, Nobutaka Ohgami, Masaru Hori, Masashi Kato

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Due to the increased ultraviolet radiation, the incidence of melanoma is increasing worldwide more than that of any other cancer. In this study, the effects of irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) on benign melanocytic tumors from our original hairless model mice (HL-RET-mice), in which benign melanocytic tumors and melanomas spontaneously develop in the skin stepwise, were examined. Expression levels of melanoma cell adhesion molecule (MCAM) and matrix metalloproteinase-2 (MMP-2) mRNA in melanomas were higher than those in benign melanocytic tumors in the mice. Repeated irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) for the benign tumors decreased the expression levels of MCAM and MMP-2 mRNA in the tumors from the mice. Previous studies showed that MCAM sites are upstream of MMP-2, that MCAM regulates transcription of MMP-2 in melanoma cells and that MMP-2 is associated with the conversion of a benign tumor to a malignant tumor. Therefore, our results suggest that the NEAPP irradiation-mediated decrease in the expression level of MMP-2 in benign melanocytic tumors is associated with decreased expression levels of MCAM. Moreover, NEAPP irradiation might be a potential candidate for therapy to prevent melanoma development through suppression of malignant conversion in benign melanocytic tumors.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalEnvironmental Health and Preventive Medicine
Volume19
Issue number5
DOIs
Publication statusPublished - 2014 Sep 18
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. / Omata, Yasuhiro; Iida, Machiko; Yajima, Ichiro; Takeda, Kozue; Ohgami, Nobutaka; Hori, Masaru; Kato, Masashi.

In: Environmental Health and Preventive Medicine, Vol. 19, No. 5, 18.09.2014, p. 367-369.

Research output: Contribution to journalArticle

Omata, Yasuhiro ; Iida, Machiko ; Yajima, Ichiro ; Takeda, Kozue ; Ohgami, Nobutaka ; Hori, Masaru ; Kato, Masashi. / Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. In: Environmental Health and Preventive Medicine. 2014 ; Vol. 19, No. 5. pp. 367-369.
@article{b0e2a8ae93d0446ea98bc6900defba34,
title = "Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma",
abstract = "Due to the increased ultraviolet radiation, the incidence of melanoma is increasing worldwide more than that of any other cancer. In this study, the effects of irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) on benign melanocytic tumors from our original hairless model mice (HL-RET-mice), in which benign melanocytic tumors and melanomas spontaneously develop in the skin stepwise, were examined. Expression levels of melanoma cell adhesion molecule (MCAM) and matrix metalloproteinase-2 (MMP-2) mRNA in melanomas were higher than those in benign melanocytic tumors in the mice. Repeated irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) for the benign tumors decreased the expression levels of MCAM and MMP-2 mRNA in the tumors from the mice. Previous studies showed that MCAM sites are upstream of MMP-2, that MCAM regulates transcription of MMP-2 in melanoma cells and that MMP-2 is associated with the conversion of a benign tumor to a malignant tumor. Therefore, our results suggest that the NEAPP irradiation-mediated decrease in the expression level of MMP-2 in benign melanocytic tumors is associated with decreased expression levels of MCAM. Moreover, NEAPP irradiation might be a potential candidate for therapy to prevent melanoma development through suppression of malignant conversion in benign melanocytic tumors.",
author = "Yasuhiro Omata and Machiko Iida and Ichiro Yajima and Kozue Takeda and Nobutaka Ohgami and Masaru Hori and Masashi Kato",
year = "2014",
month = "9",
day = "18",
doi = "10.1007/s12199-014-0399-1",
language = "English",
volume = "19",
pages = "367--369",
journal = "Environmental Health and Preventive Medicine",
issn = "1342-078X",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma

AU - Omata, Yasuhiro

AU - Iida, Machiko

AU - Yajima, Ichiro

AU - Takeda, Kozue

AU - Ohgami, Nobutaka

AU - Hori, Masaru

AU - Kato, Masashi

PY - 2014/9/18

Y1 - 2014/9/18

N2 - Due to the increased ultraviolet radiation, the incidence of melanoma is increasing worldwide more than that of any other cancer. In this study, the effects of irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) on benign melanocytic tumors from our original hairless model mice (HL-RET-mice), in which benign melanocytic tumors and melanomas spontaneously develop in the skin stepwise, were examined. Expression levels of melanoma cell adhesion molecule (MCAM) and matrix metalloproteinase-2 (MMP-2) mRNA in melanomas were higher than those in benign melanocytic tumors in the mice. Repeated irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) for the benign tumors decreased the expression levels of MCAM and MMP-2 mRNA in the tumors from the mice. Previous studies showed that MCAM sites are upstream of MMP-2, that MCAM regulates transcription of MMP-2 in melanoma cells and that MMP-2 is associated with the conversion of a benign tumor to a malignant tumor. Therefore, our results suggest that the NEAPP irradiation-mediated decrease in the expression level of MMP-2 in benign melanocytic tumors is associated with decreased expression levels of MCAM. Moreover, NEAPP irradiation might be a potential candidate for therapy to prevent melanoma development through suppression of malignant conversion in benign melanocytic tumors.

AB - Due to the increased ultraviolet radiation, the incidence of melanoma is increasing worldwide more than that of any other cancer. In this study, the effects of irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) on benign melanocytic tumors from our original hairless model mice (HL-RET-mice), in which benign melanocytic tumors and melanomas spontaneously develop in the skin stepwise, were examined. Expression levels of melanoma cell adhesion molecule (MCAM) and matrix metalloproteinase-2 (MMP-2) mRNA in melanomas were higher than those in benign melanocytic tumors in the mice. Repeated irradiation of non-thermal atmospheric pressure plasmas (NEAPPs) for the benign tumors decreased the expression levels of MCAM and MMP-2 mRNA in the tumors from the mice. Previous studies showed that MCAM sites are upstream of MMP-2, that MCAM regulates transcription of MMP-2 in melanoma cells and that MMP-2 is associated with the conversion of a benign tumor to a malignant tumor. Therefore, our results suggest that the NEAPP irradiation-mediated decrease in the expression level of MMP-2 in benign melanocytic tumors is associated with decreased expression levels of MCAM. Moreover, NEAPP irradiation might be a potential candidate for therapy to prevent melanoma development through suppression of malignant conversion in benign melanocytic tumors.

UR - http://www.scopus.com/inward/record.url?scp=84919498208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919498208&partnerID=8YFLogxK

U2 - 10.1007/s12199-014-0399-1

DO - 10.1007/s12199-014-0399-1

M3 - Article

VL - 19

SP - 367

EP - 369

JO - Environmental Health and Preventive Medicine

JF - Environmental Health and Preventive Medicine

SN - 1342-078X

IS - 5

ER -