Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle

Masahiro Shibata, S. Ichioka, J. Ando, A. Kamiya, T. Togawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The tissue pO 2-dependent regulation of microvascular blood flow was evaluated in rabbit skeletal muscle in vivo. The rabbit tenuissimus muscle was prepared to observe the microcirculation. The capillary red blood cell velocity and perfused capillary density at various tissue pO 2 levels were measured from the images of microcirculation obtained by an intravital video-microscope. Both velocity and density were significantly decreased as tissue pO 2 was elevated, but the relationship between capillary flow and tissue pO 2 was not a linear correlation. In addition, the critical pO 2 value effected on microvascular blood flow regulation might exist in the tissue pO 2 ranging between 30 to 50 ninvllg. It is suggested that the arteriolar walls might detect such a pO 2 value and control capillary blood flow directly by influencing the tonus of their smooth muscle.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages462-463
Number of pages2
Volume1
Publication statusPublished - 2003
Externally publishedYes
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: 2003 Sep 172003 Sep 21

Other

OtherA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryMexico
CityCancun
Period03/9/1703/9/21

Fingerprint

Muscle
Blood
Tissue
Microcirculation
Capillary flow
Microscopes
Cells
PO-2

Keywords

  • Capillary blood flow
  • Skeletal muscle
  • Tissue pO

ASJC Scopus subject areas

  • Bioengineering

Cite this

Shibata, M., Ichioka, S., Ando, J., Kamiya, A., & Togawa, T. (2003). Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle In R. S. Leder (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 462-463)

Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle . / Shibata, Masahiro; Ichioka, S.; Ando, J.; Kamiya, A.; Togawa, T.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / R.S. Leder. Vol. 1 2003. p. 462-463.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shibata, M, Ichioka, S, Ando, J, Kamiya, A & Togawa, T 2003, Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, pp. 462-463, A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 03/9/17.
Shibata M, Ichioka S, Ando J, Kamiya A, Togawa T. Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle In Leder RS, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. 2003. p. 462-463
Shibata, Masahiro ; Ichioka, S. ; Ando, J. ; Kamiya, A. ; Togawa, T. / Nonlinear Control of Microvascular Blood Flow against Tissue PO 2 in Skeletal Muscle Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / R.S. Leder. Vol. 1 2003. pp. 462-463
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