Abstract
Mapping of the activity of brain by optical intrinsic signal imaging (OISI) provides a two-dimensional activation pattern of visual cortical areas at a resolution of a few hundred microns. However, integration of the intrinsic signal over depth results in loss of finer information about functional organization across the depth. Here, we report the first successful implementation of optical coherence tomography (OCT) at around 30 μm depth resolution to investigate cortical functions of a cat brain in vivo. This technique, named functional OCT (fOCT) provided visually evoked changes in the OCT signal. The fOCT signal shows stimulus specificity that correlates well with that of the intrinsic signals and provides depth resolved layer specific functional information.
| Original language | English |
|---|---|
| Pages (from-to) | 83-92 |
| Number of pages | 10 |
| Journal | Journal of Neuroscience Methods |
| Volume | 124 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Mar 30 |
| Externally published | Yes |
Keywords
- Depth resolved functional profile
- Functional optical coherence tomography
- Optical coherence tomography
- Optical intrinsic signal imaging
- Primary visual cortex
- Scattering change
- Visualization of neural activity
- Volumetric functional imaging
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Novel functional imaging technique from brain surface with optical coherence tomography enabling visualization of depth resolved functional structure in vivo. / Umamaheswari, Rajagopalan; Takaoka, H.; Kadono, H.; Homma, R.; Tanifuji, M.
In: Journal of Neuroscience Methods, Vol. 124, No. 1, 30.03.2003, p. 83-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Novel functional imaging technique from brain surface with optical coherence tomography enabling visualization of depth resolved functional structure in vivo
AU - Umamaheswari, Rajagopalan
AU - Takaoka, H.
AU - Kadono, H.
AU - Homma, R.
AU - Tanifuji, M.
PY - 2003/3/30
Y1 - 2003/3/30
N2 - Mapping of the activity of brain by optical intrinsic signal imaging (OISI) provides a two-dimensional activation pattern of visual cortical areas at a resolution of a few hundred microns. However, integration of the intrinsic signal over depth results in loss of finer information about functional organization across the depth. Here, we report the first successful implementation of optical coherence tomography (OCT) at around 30 μm depth resolution to investigate cortical functions of a cat brain in vivo. This technique, named functional OCT (fOCT) provided visually evoked changes in the OCT signal. The fOCT signal shows stimulus specificity that correlates well with that of the intrinsic signals and provides depth resolved layer specific functional information.
AB - Mapping of the activity of brain by optical intrinsic signal imaging (OISI) provides a two-dimensional activation pattern of visual cortical areas at a resolution of a few hundred microns. However, integration of the intrinsic signal over depth results in loss of finer information about functional organization across the depth. Here, we report the first successful implementation of optical coherence tomography (OCT) at around 30 μm depth resolution to investigate cortical functions of a cat brain in vivo. This technique, named functional OCT (fOCT) provided visually evoked changes in the OCT signal. The fOCT signal shows stimulus specificity that correlates well with that of the intrinsic signals and provides depth resolved layer specific functional information.
KW - Depth resolved functional profile
KW - Functional optical coherence tomography
KW - Optical coherence tomography
KW - Optical intrinsic signal imaging
KW - Primary visual cortex
KW - Scattering change
KW - Visualization of neural activity
KW - Volumetric functional imaging
UR - http://www.scopus.com/inward/record.url?scp=0037473238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037473238&partnerID=8YFLogxK
U2 - 10.1016/S0165-0270(02)00370-9
DO - 10.1016/S0165-0270(02)00370-9
M3 - Article
C2 - 12648767
AN - SCOPUS:0037473238
VL - 124
SP - 83
EP - 92
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
IS - 1
ER -