Abstract
The reaction of ninhydrin with (+)-catechin in the presence of TMSOTf resulted in condensation product 1, which consists of a 2:1 mixture of epimers at the C-2 position. The antioxidative radical-scavenging activity of 1 against the galvinoxyl radical, acting as an oxyl radical, was significantly enhanced compared to (+)-catechin. Our results offer a new method for chemical modification of a natural phenolic antioxidant.
Original language | English |
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Pages (from-to) | 6989-6992 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 50 |
DOIs | |
Publication status | Published - 2009 Dec 16 |
Keywords
- Antioxidant
- Catechin
- Galvinoxyl radical
- Ninhydrin
- Radical scavenging
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry