Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.

Kenatarou Watanabe, Toyofusa Katou, Yasunori Ikezawa, Saki Yajima, Hirohito Shionoya, Takashi Akagi, Keita Hamasaki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.

Original languageEnglish
Pages (from-to)209-210
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Watanabe, K., Katou, T., Ikezawa, Y., Yajima, S., Shionoya, H., Akagi, T., & Hamasaki, K. (2007). Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA. Nucleic acids symposium series (2004), (51), 209-210.