Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1

Ryo Inoue; Kentarou Watanabe; Toyofusa Katou; Yasunori Ikezawa; Keita Hamasaki

doi:10.1016/j.bmc.2015.03.001

Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1

Ryo Inoue, Kentarou Watanabe, Toyofusa Katou, Yasunori Ikezawa, Keita Hamasaki

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied. NbK-neamines were bind those RNAs with micro molar level of binding affinities and compete with corresponding activator peptide for TAR RNA, but not for RRE RNA. GbK-neamine denotes the highest binding affinity with TAR RNA, three to five times higher than other three NbK-neamines. GbK-neamine could be a candidate of potential inhibitor for TAR-Tat.

Original language	English
Pages (from-to)	2139-2147
Number of pages	9
Journal	Bioorganic and Medicinal Chemistry
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/j.bmc.2015.03.001
Publication status	Published - 2015 May 1

Keywords

Aminoglycoside
Neamine
Nucleobase
Potential inhibitor
RRE RNA
TAR RNA

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2015.03.001

Fingerprint Dive into the research topics of 'Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1'. Together they form a unique fingerprint.

Cite this

@article{19ed9a02e1b2412fa5f3b9332cb15d9a,

title = "Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1",

abstract = "Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied. NbK-neamines were bind those RNAs with micro molar level of binding affinities and compete with corresponding activator peptide for TAR RNA, but not for RRE RNA. GbK-neamine denotes the highest binding affinity with TAR RNA, three to five times higher than other three NbK-neamines. GbK-neamine could be a candidate of potential inhibitor for TAR-Tat.",

keywords = "Aminoglycoside, Neamine, Nucleobase, Potential inhibitor, RRE RNA, TAR RNA",

author = "Ryo Inoue and Kentarou Watanabe and Toyofusa Katou and Yasunori Ikezawa and Keita Hamasaki",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.bmc.2015.03.001",

language = "English",

volume = "23",

pages = "2139--2147",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1

AU - Inoue, Ryo

AU - Watanabe, Kentarou

AU - Katou, Toyofusa

AU - Ikezawa, Yasunori

AU - Hamasaki, Keita

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied. NbK-neamines were bind those RNAs with micro molar level of binding affinities and compete with corresponding activator peptide for TAR RNA, but not for RRE RNA. GbK-neamine denotes the highest binding affinity with TAR RNA, three to five times higher than other three NbK-neamines. GbK-neamine could be a candidate of potential inhibitor for TAR-Tat.

AB - Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied. NbK-neamines were bind those RNAs with micro molar level of binding affinities and compete with corresponding activator peptide for TAR RNA, but not for RRE RNA. GbK-neamine denotes the highest binding affinity with TAR RNA, three to five times higher than other three NbK-neamines. GbK-neamine could be a candidate of potential inhibitor for TAR-Tat.

KW - Aminoglycoside

KW - Neamine

KW - Nucleobase

KW - Potential inhibitor

KW - RRE RNA

KW - TAR RNA

UR - http://www.scopus.com/inward/record.url?scp=84939994352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939994352&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2015.03.001

DO - 10.1016/j.bmc.2015.03.001

M3 - Article

C2 - 25819332

AN - SCOPUS:84939994352

VL - 23

SP - 2139

EP - 2147

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 9

ER -

Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this