Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1

Ryo Inoue, Kentarou Watanabe, Toyofusa Katou, Yasunori Ikezawa, Keita Hamasaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied. NbK-neamines were bind those RNAs with micro molar level of binding affinities and compete with corresponding activator peptide for TAR RNA, but not for RRE RNA. GbK-neamine denotes the highest binding affinity with TAR RNA, three to five times higher than other three NbK-neamines. GbK-neamine could be a candidate of potential inhibitor for TAR-Tat.

Original languageEnglish
Pages (from-to)2139-2147
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume23
Issue number9
DOIs
Publication statusPublished - 2015 May 1

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Lysine
RNA
neamine
Peptides

Keywords

  • Aminoglycoside
  • Neamine
  • Nucleobase
  • Potential inhibitor
  • RRE RNA
  • TAR RNA

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1. / Inoue, Ryo; Watanabe, Kentarou; Katou, Toyofusa; Ikezawa, Yasunori; Hamasaki, Keita.

In: Bioorganic and Medicinal Chemistry, Vol. 23, No. 9, 01.05.2015, p. 2139-2147.

Research output: Contribution to journalArticle

Inoue, Ryo ; Watanabe, Kentarou ; Katou, Toyofusa ; Ikezawa, Yasunori ; Hamasaki, Keita. / Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1. In: Bioorganic and Medicinal Chemistry. 2015 ; Vol. 23, No. 9. pp. 2139-2147.
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