Omnidirectional actuation of magnetically driven microtool for cutting of oocyte in a chip

Naoki Inomata, Takehito Mizunuma, Yoko Yamanishi, Fumihito Arai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In this paper, we developed and fabricated a magnetically driven microtool (MMT) and installed it on a microfluidic chip for use in the enucleation of oocytes. The fabricated tool is much smaller than a conventional mechanical micromanipulator used for cell manipulation. We succeeded in driving this MMT in two degrees of freedomin the X - and Y -directions. The MMT works on the principle of noncontact actuation by magnetic force; therefore, the microfluidic-chip part is fully disposable and inexpensive. The MMT consists of a polymer part with a controllable attitude and a rigid metal (Ni) part with good magnetic properties, which are useful for cutting oocytes. We analytically evaluated that the structure for easy attitude control of the polymer part is a four-leg-type configuration. Based on the novel and original design, the MMT and microfluidic chip were fabricated by photolithography. The MMT could generate a force of 3 mN, which is sufficient to cut an oocyte into half. We successfully demonstrated the cutting of an oocyte on a microfluidic chip by using the MMT.

Original languageEnglish
Article number5686907
Pages (from-to)383-388
Number of pages6
JournalJournal of Microelectromechanical Systems
Volume20
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1

Keywords

  • Enucleation
  • magnetically driven microtool (MMT)
  • microfluidic chip
  • oocyte

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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