On-chip temperature sensing and control for cell immobilization

Yu Ching Lin, Yoko Yamanishi, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Abstract

In this study, a temperature sensing and controlling microfluid chip has been developed for cell immobilization using a thermo-sensitive hydrogel (PNIPAAm). The PDMS-based micromagnetic stirrers make microscale fluid mixing to provide the temperature stability in the microchannel. The ITO (Indium Tin Oxide) microheaters and thermosensors, fabricated by micromachining technology, perform in situ fluid heating and feedback temperature control. All temperature sensing and controlling devices are integrated on a chip, in which yeast cell immobilization is performed by the gelation of the PNIPAAm solution.

Original languageEnglish
Title of host publicationProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages659-663
Number of pages5
DOIs
Publication statusPublished - 2007
Externally publishedYes
Event2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok
Duration: 2007 Jan 162007 Jan 19

Other

Other2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
CityBangkok
Period07/1/1607/1/19

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Keywords

  • Cell immobilization
  • ITO
  • PDMS
  • Stirrer
  • Temperature

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications
  • Electrical and Electronic Engineering

Cite this

Lin, Y. C., Yamanishi, Y., & Arai, F. (2007). On-chip temperature sensing and control for cell immobilization. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 659-663). [4160408] https://doi.org/10.1109/NEMS.2007.352105