Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Takahiro Kono, Nobuaki Imanishi, Keiko Nozawa, Atsuo Takashima, Rajagopalan Umamaheswari, Hiroki Gonome, Jun Yamada

Research output: Contribution to journalArticle


The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

Original languageEnglish
Article number366571
Pages (from-to)3747-3759
Number of pages13
JournalBiomedical Optics Express
Issue number8
Publication statusPublished - 2019 Aug 1


ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this