Optimum capillary number for oxygen delivery to tissue in man

Akira Kamiya, Shinya Takeda, Masahiro Shibata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The optimum number of total capillaries in the whole human body was estimated from the analysis of the efficiency for oxygen (O2) transport in the vascular-tissue system. We used a tissue model composed of uniform spheres in which O2 diffuses from the capillary located at the centre of each sphere towards the surrounding tissue consuming O2 at a constant rate. The tissue mass supplied by a single capillary was estimated as the area of positive O2 concentration under a given condition of capillary flow and O2 consumption rate. Total tissue mass was determined as the function of the capillary number n and the total blood flow. On the other hand, the energy cost required to maintain the vascular system with n terminals was assessed by using the minimum volume model (Kamiya and Togawa, Bull. math. Biophys. 34, 431-438, 1972). The efficiency of the entire vascular-tissue system was evaluated by calculating the ratio of total tissue mass/cost function. The result of the calculation using physiological data of cardiac output and O2 consumption for an average human adult during a heavy exercise revealed the maximum efficiency occurring at the capillary number 3.7×1010 which coincided well with its normal range of physiological estimates (3.2×1010-4.2×1010). We concluded that the entire vascular-tissue system is constructed so as to attain the highest efficiency in O2 transport at its maximum activity.

Original languageEnglish
Pages (from-to)351-361
Number of pages11
JournalBulletin of Mathematical Biology
Volume49
Issue number3
DOIs
Publication statusPublished - 1987 May

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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