Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis

M. Shibata, N. Ohura, S. Ichioka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured during enhancement and inhibition of NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the intra-and peri-vascular oxygen tension (PO2) measured by phosphorescence quenching microscopy. The inhibition of NO synthesis increased the oxygen consumption rate of the vessel walls by 42%, whereas enhancement of flow-induced NO release decreased it by 34%. These results suggest that NO plays an important role not only as a regulator of peripheral vascular tone, but also as a modulator of tissue oxygen consumption by reducing oxygen consumption by vessel walls.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Pages125-128
Number of pages4
Edition4
DOIs
Publication statusPublished - 2009 Dec 1
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: 2009 Sep 72009 Sep 12

Publication series

NameIFMBE Proceedings
Number4
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period09/9/709/9/12

    Fingerprint

Keywords

  • Microcirculation
  • Phosphorescence quenching
  • Skeletal muscle
  • Vasoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Shibata, M., Ohura, N., & Ichioka, S. (2009). Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis. In World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics (4 ed., pp. 125-128). (IFMBE Proceedings; Vol. 25, No. 4). https://doi.org/10.1007/978-3-642-03882-2-32