Oxygen consumption of keloids and hypertrophic scars

Shigeru Ichioka, Taichi Ando, Masahiro Shibata, Naomi Sekiya, Takashi Nakatsuka

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalAnnals of Plastic Surgery
Volume60
Issue number2
DOIs
Publication statusPublished - 2008 Feb

Keywords

  • Clark electrode
  • Hypertrophic scar
  • Keloid
  • Oxygen consumption
  • Wound healing

ASJC Scopus subject areas

  • Surgery

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