Abstract
The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.
| Original language | English |
|---|---|
| Pages (from-to) | 194-197 |
| Number of pages | 4 |
| Journal | Annals of Plastic Surgery |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Feb |
| Externally published | Yes |
Keywords
- Clark electrode
- Hypertrophic scar
- Keloid
- Oxygen consumption
- Wound healing
ASJC Scopus subject areas
- Surgery
Cite this
Oxygen consumption of keloids and hypertrophic scars. / Ichioka, Shigeru; Ando, Taichi; Shibata, Masahiro; Sekiya, Naomi; Nakatsuka, Takashi.
In: Annals of Plastic Surgery, Vol. 60, No. 2, 02.2008, p. 194-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oxygen consumption of keloids and hypertrophic scars
AU - Ichioka, Shigeru
AU - Ando, Taichi
AU - Shibata, Masahiro
AU - Sekiya, Naomi
AU - Nakatsuka, Takashi
PY - 2008/2
Y1 - 2008/2
N2 - The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.
AB - The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.
KW - Clark electrode
KW - Hypertrophic scar
KW - Keloid
KW - Oxygen consumption
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=38549168379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38549168379&partnerID=8YFLogxK
U2 - 10.1097/SAP.0b013e318053ec1d
DO - 10.1097/SAP.0b013e318053ec1d
M3 - Article
VL - 60
SP - 194
EP - 197
JO - Annals of Plastic Surgery
JF - Annals of Plastic Surgery
SN - 0148-7043
IS - 2
ER -