Photoacoustic mammography: Initial clinical results

Toshiyuki Kitai, Masae Torii, Tomoharu Sugie, Shotaro Kanao, Yoshiki Mikami, Tsuyoshi Shiina, Masakazu Toi

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

Purpose: Photoacoustic tomography can image the hemoglobin distribution and oxygenation state inside tissue with high spatial resolution. The purpose of this study is to investigate its clinical usefulness for diagnosis of breast cancer and evaluation of therapeutic response in relation to other diagnostic modalities. Materials and methods: Using a prototype machine for photoacoustic mammography (PAM), 27 breast tumor lesions, including 21 invasive breast cancer (IBC), five ductal carcinoma in situ (DCIS), and one phyllodes tumor, were measured. Nine out of twenty-one IBC patients had received primary systemic therapy (PST). Results: Eight out of twelve IBC without PST were visible. Notably, detection was possible in all five cases with DCIS, whereas it was not in one case with phyllodes tumor. Seven out of nine IBC with PST were assigned as visible in spite of decreased size of tumor after PST. The mean value of hemoglobin saturation in the visible lesions was 78.6 %, and hemoglobin concentration was 207 μM. The tumor images of PAM were comparable to those of magnetic resonance imaging (MRI). Conclusions: It is suggested that PAM can image tumor vascularity and oxygenation, which may be useful for diagnosis and characterization of breast cancer.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalBreast Cancer
Volume21
Issue number2
DOIs
Publication statusPublished - 2014 Mar
Externally publishedYes

Keywords

  • Breast cancer
  • Near-infrared
  • Optical imaging
  • Oxygenation
  • Photoacoustic mammography
  • Tumor vascularity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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