Photodynamic assistance increases the efficiency of the process of microinjection in animal cells

Takashi K. Saito, Hitoshi Muguruma, Kunihiko Mabuchi

Research output: Contribution to journalArticle

14 Citations (Scopus)


A microinjection process is described that involves the photodynamically-assisted puncture of an animal cell membrane by means of a brief and partial degeneration resulting from cell membrane damage. The ratio of dye-injected rat pheochromocytoma cells that became detached three and six days after photodynamically-assisted microinjection was 9%; however, it was 83% when a conventional mechanical microinjection process was used.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalBiotechnology Letters
Issue number4
Publication statusPublished - 2002



  • α-terthienyl derivative
  • Detachment assay
  • Microinjection
  • Photodynamic membrane damage
  • Rat PC12 cell line

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this