Physiological role of nitric oxide in oxygen consumption by arteriolar wall

Masahiro Shibata, Takehiro Yamakoshi, Ken Ichi Yamakoshi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured in vivo during flow-induced vasodilation and after inhibiting NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the intra- and peri-vascular oxygen tension (PO2) values measured by phosphorescence quenching laser microscopy. The peri-vascular PO2 value of the arterioles during vasodilation was significantly higher than under control conditions, although the intravascular PO2 values under both conditions were approximately the same. On the other hand, inhibition of NO synthesis caused a significant decrease in both the intra- and peri-vascular PO2 values of the arterioles. The inhibition of NO synthesis increased the oxygen consumption rate of the vessel walls by 42%, whereas enhancement of flow-induced NO release decreased it by 34%. These results suggest that NO plays an important role not only as a regulator of peripheral vascular tone, but also as a modulator of tissue oxygen consumption by reducing oxygen consumption by vessel walls.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages1389-1392
Number of pages4
Publication statusPublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC
Duration: 2008 Aug 202008 Aug 25

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CityVancouver, BC
Period08/8/2008/8/25

Fingerprint

Nitric oxide
Oxygen
Phosphorescence
Modulators
Muscle
Rats
Quenching
Microscopic examination
Tissue
Lasers

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Shibata, M., Yamakoshi, T., & Yamakoshi, K. I. (2008). Physiological role of nitric oxide in oxygen consumption by arteriolar wall. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 1389-1392). [4649424]

Physiological role of nitric oxide in oxygen consumption by arteriolar wall. / Shibata, Masahiro; Yamakoshi, Takehiro; Yamakoshi, Ken Ichi.

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 1389-1392 4649424.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shibata, M, Yamakoshi, T & Yamakoshi, KI 2008, Physiological role of nitric oxide in oxygen consumption by arteriolar wall. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"., 4649424, pp. 1389-1392, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, 08/8/20.
Shibata M, Yamakoshi T, Yamakoshi KI. Physiological role of nitric oxide in oxygen consumption by arteriolar wall. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 1389-1392. 4649424
Shibata, Masahiro ; Yamakoshi, Takehiro ; Yamakoshi, Ken Ichi. / Physiological role of nitric oxide in oxygen consumption by arteriolar wall. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. pp. 1389-1392
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