Plasmonic exosome biosensors for medical diagnostics

Agnes T. Reiner, Koji Toma, Alain R. Brisson, Dietmar Pils, Wolfgang Knoll, Jakub Dostalek

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

This chapter provides an overview of plasmonic biosensor technology for the analysis of extracellular lipid vesicles that hold potential to serve as new type of biomarkers. In particular, it discusses detection of exosomes that are secreted to bodily fluids and become of increasing interest in clinical research. Plasmonic biosensor technology is pushed forward to provide new means for their sensitive and specific detection without the need of specialized laboratories. It offers a versatile optical toolbox for probing various biological species by tightly confined electromagnetic field of surface plasmons. These optical waves originate from collective oscillations of electron charge density at metallic thin films and (nano) structures. This chapter gives an introduction to surface plasmon photonics and its use in direct surface plasmon resonance and in fluorescence spectroscopy-based biosensors. It provides a brief summary of current state-of-the-art in exosome biomarker research and discusses current advances in exosome plasmonic biosensors for medical diagnostics of diseases, in particular cancer.

Original languageEnglish
Title of host publicationFrontiers in Biophotonics for Translational Medicine
Subtitle of host publicationIn the Celebration of Year of Light (2015)
PublisherSpringer Singapore
Pages249-272
Number of pages24
ISBN (Electronic)9789812876270
ISBN (Print)9789812876263
DOIs
Publication statusPublished - 2015 Jul 3
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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