TY - JOUR
T1 - Plastic strains during stent deployment have a critical influence on the rate of corrosion in absorbable magnesium stents
AU - Galvin, Emmet
AU - Cummins, Christy
AU - Yoshihara, Shoichiro
AU - Mac Donald, Bryan J.
AU - Lally, Caitríona
N1 - Publisher Copyright:
© 2016, International Federation for Medical and Biological Engineering.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Magnesium stents are a promising candidate in the emerging field of absorbable metallic stents (AMSs). In this study, the mechanical and corrosion performance of dog-bone specimens and a specific stent design of a magnesium alloy, WE43, are assessed experimentally in terms of their corrosion behaviour and mechanical integrity. It is shown that plastic strains that are induced in the struts of the stent during stent deployment have a critical influence in directing subsequent corrosion behaviour within the material. In addition, the deployment and scaffolding characteristics of the magnesium stent are elucidated and contrasted with those of a commercial stainless steel stent. The magnesium stent is found to support higher levels of cyclic strain amplitude than the stainless steel stent, even prior to degradation, and this may play a role in reducing in-stent restenosis. This study provides new insights into the experimental performance of a current AMS design and material whilst demonstrating the critical influence of plastic strain on the corrosion performance and scaffolding ability of an AMS.
AB - Magnesium stents are a promising candidate in the emerging field of absorbable metallic stents (AMSs). In this study, the mechanical and corrosion performance of dog-bone specimens and a specific stent design of a magnesium alloy, WE43, are assessed experimentally in terms of their corrosion behaviour and mechanical integrity. It is shown that plastic strains that are induced in the struts of the stent during stent deployment have a critical influence in directing subsequent corrosion behaviour within the material. In addition, the deployment and scaffolding characteristics of the magnesium stent are elucidated and contrasted with those of a commercial stainless steel stent. The magnesium stent is found to support higher levels of cyclic strain amplitude than the stainless steel stent, even prior to degradation, and this may play a role in reducing in-stent restenosis. This study provides new insights into the experimental performance of a current AMS design and material whilst demonstrating the critical influence of plastic strain on the corrosion performance and scaffolding ability of an AMS.
KW - Absorbable metallic stents
KW - Biodegradable magnesium alloys
KW - Biomaterials
KW - Cyclic strain
KW - WE43
UR - http://www.scopus.com/inward/record.url?scp=84992409166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992409166&partnerID=8YFLogxK
U2 - 10.1007/s11517-016-1584-8
DO - 10.1007/s11517-016-1584-8
M3 - Article
AN - SCOPUS:84992409166
SN - 0140-0118
VL - 55
SP - 1261
EP - 1275
JO - Medical and Biological Engineering and Computing
JF - Medical and Biological Engineering and Computing
IS - 8
ER -