PLP-I: A novel prolactin-like gene in rodents

Yoshiki Hiraoka, Motoyuki Ogawa, Yukinao Sakai, Yuji Takeuchi, Naoki Komatsu, Masahide Shiozawa, Kiyoo Tanabe, Sadakazu Aiso

Research output: Contribution to journalArticle

15 Citations (Scopus)


In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Issue number2-3
Publication statusPublished - 1999 Oct 28
Externally publishedYes


  • Decidua
  • Phylogenetic tree
  • Prolactin
  • cDNA

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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  • Cite this

    Hiraoka, Y., Ogawa, M., Sakai, Y., Takeuchi, Y., Komatsu, N., Shiozawa, M., Tanabe, K., & Aiso, S. (1999). PLP-I: A novel prolactin-like gene in rodents. Biochimica et Biophysica Acta - Gene Structure and Expression, 1447(2-3), 291-297.