PLP-I: A novel prolactin-like gene in rodents

Yoshiki Hiraoka, Motoyuki Ogawa, Yukinao Sakai, Yuji Takeuchi, Naoki Komatsu, Masahide Shiozawa, Kiyoo Tanabe, Sadakazu Aiso

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

In this report, we describe molecular cloning and characterization of cDNAs encoding a novel rat prolactin-like protein. The rat cDNAs were isolated from the decidua and the gene was named PLP-I. cDNAs for the mouse equivalent were also cloned by the cross-hybridization technique. Pregnancy-specific expression of the rat PLP-I gene was observed in the rat placenta by Northern analysis. Location of signal peptide cleavage sites in rat and mouse pre-PLP-I proteins was predicted using a theoretical method. A molecular phylogenetic tree for the growth hormone-prolactin superfamily including the novel member, PLP-I, constructed using the neighbor-joining method, places rat/mouse PLP-I closest to rat/mouse placental lactogen I and II. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1447
Issue number2-3
DOIs
Publication statusPublished - 1999 Oct 28
Externally publishedYes

Fingerprint

Prolactin
Rats
Genes
Complementary DNA
Cloning
Protein Sorting Signals
Rodentia
Joining
Growth Hormone
Proteins

Keywords

  • cDNA
  • Decidua
  • Phylogenetic tree
  • Prolactin

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

Cite this

PLP-I : A novel prolactin-like gene in rodents. / Hiraoka, Yoshiki; Ogawa, Motoyuki; Sakai, Yukinao; Takeuchi, Yuji; Komatsu, Naoki; Shiozawa, Masahide; Tanabe, Kiyoo; Aiso, Sadakazu.

In: Biochimica et Biophysica Acta - Gene Structure and Expression, Vol. 1447, No. 2-3, 28.10.1999, p. 291-297.

Research output: Contribution to journalReview article

Hiraoka, Y, Ogawa, M, Sakai, Y, Takeuchi, Y, Komatsu, N, Shiozawa, M, Tanabe, K & Aiso, S 1999, 'PLP-I: A novel prolactin-like gene in rodents', Biochimica et Biophysica Acta - Gene Structure and Expression, vol. 1447, no. 2-3, pp. 291-297. https://doi.org/10.1016/S0167-4781(99)00160-8
Hiraoka Y, Ogawa M, Sakai Y, Takeuchi Y, Komatsu N, Shiozawa M et al. PLP-I: A novel prolactin-like gene in rodents. Biochimica et Biophysica Acta - Gene Structure and Expression. 1999 Oct 28;1447(2-3):291-297. https://doi.org/10.1016/S0167-4781(99)00160-8
Hiraoka, Yoshiki ; Ogawa, Motoyuki ; Sakai, Yukinao ; Takeuchi, Yuji ; Komatsu, Naoki ; Shiozawa, Masahide ; Tanabe, Kiyoo ; Aiso, Sadakazu. / PLP-I : A novel prolactin-like gene in rodents. In: Biochimica et Biophysica Acta - Gene Structure and Expression. 1999 ; Vol. 1447, No. 2-3. pp. 291-297.
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