Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls

Hirokazu Atsumori, Akiko N. Obata, Hiroki Satou, Tsukasa Funane, Ritsuko Yamaguchi, Masashi Kiguchi

Research output: Contribution to journalArticle

Abstract

The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual's mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of biomedical optics
Volume24
Issue number5
DOIs
Publication statusPublished - 2019 May 1
Externally publishedYes

Fingerprint

cortexes
students
Chemical activation
activation
disorders
moods
Near infrared spectroscopy
Biomarkers
biomarkers
logistics
Logistics
imaging techniques
monitors
regression analysis
Imaging techniques
Data storage equipment
Recovery
receivers
recovery
infrared spectroscopy

Keywords

  • mood state
  • near-infrared spectroscopy
  • prefrontal cortex
  • return to work
  • working memory

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls. / Atsumori, Hirokazu; Obata, Akiko N.; Satou, Hiroki; Funane, Tsukasa; Yamaguchi, Ritsuko; Kiguchi, Masashi.

In: Journal of biomedical optics, Vol. 24, No. 5, 01.05.2019, p. 1-7.

Research output: Contribution to journalArticle

Atsumori, Hirokazu ; Obata, Akiko N. ; Satou, Hiroki ; Funane, Tsukasa ; Yamaguchi, Ritsuko ; Kiguchi, Masashi. / Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls. In: Journal of biomedical optics. 2019 ; Vol. 24, No. 5. pp. 1-7.
@article{e6d267db2bf240a8a7cadace56bee229,
title = "Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls",
abstract = "The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual's mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.",
keywords = "mood state, near-infrared spectroscopy, prefrontal cortex, return to work, working memory",
author = "Hirokazu Atsumori and Obata, {Akiko N.} and Hiroki Satou and Tsukasa Funane and Ritsuko Yamaguchi and Masashi Kiguchi",
year = "2019",
month = "5",
day = "1",
doi = "10.1117/1.JBO.24.5.056008",
language = "English",
volume = "24",
pages = "1--7",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "5",

}

TY - JOUR

T1 - Prefrontal cortex activation of return-to-work trainees in remission of mental disorders with depressive symptoms compared to that of healthy controls

AU - Atsumori, Hirokazu

AU - Obata, Akiko N.

AU - Satou, Hiroki

AU - Funane, Tsukasa

AU - Yamaguchi, Ritsuko

AU - Kiguchi, Masashi

PY - 2019/5/1

Y1 - 2019/5/1

N2 - The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual's mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.

AB - The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual's mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.

KW - mood state

KW - near-infrared spectroscopy

KW - prefrontal cortex

KW - return to work

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=85067311923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067311923&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.24.5.056008

DO - 10.1117/1.JBO.24.5.056008

M3 - Article

VL - 24

SP - 1

EP - 7

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 5

ER -