TY - JOUR
T1 - Preparation of gradient-type biological tissue–polymer complex for interlinking device
AU - Zhang, Yongwei
AU - Nam, Kwangwoo
AU - Kimura, Tsuyoshi
AU - Wu, Pingli
AU - Nakamura, Naoko
AU - Hashimoto, Yoshihide
AU - Funamoto, Seiichi
AU - Kishida, Akio
N1 - Funding Information:
We thank Helen McPherson, PhD from Edanz Group ( www.edanzediting.com/ac ) for editing a draft of this manuscript. This research was supported in part by a Grant-in-Aid for Scientific Research (B) ( 16H03180 ) from Japan Society for the Promotion of Science (JPSP) and Research Project of Viable Materials, TMDU , Japan.
Publisher Copyright:
© 2020 The Authors
PY - 2020/9
Y1 - 2020/9
N2 - The aim of this study was to investigate the monomer absorption behavior of decellularized dermis and prepare a gradient-type decellularized dermis–polymer complex. Decellularized dermis was prepared using sodium dodecyl sulfate, and its monomer absorption behavior was investigated using three types of hydrophobic monomer with different surface free energies. The results show that monomer absorption depends strongly on the tissue structure, regardless of the surface free energy, and the amount of absorbed monomer can be increased by sonication. Based on these results, we prepared a gradient-type decellularized dermis–poly(methyl methacrylate) complex by controlling the permeation time of the methyl methacrylate monomer and polymerization initiator into the decellularized dermis. The mechanical strength of this complex gradually increased from the dermis side to the polymer side, and combined the physical characteristics of the dermis and the polymer.
AB - The aim of this study was to investigate the monomer absorption behavior of decellularized dermis and prepare a gradient-type decellularized dermis–polymer complex. Decellularized dermis was prepared using sodium dodecyl sulfate, and its monomer absorption behavior was investigated using three types of hydrophobic monomer with different surface free energies. The results show that monomer absorption depends strongly on the tissue structure, regardless of the surface free energy, and the amount of absorbed monomer can be increased by sonication. Based on these results, we prepared a gradient-type decellularized dermis–poly(methyl methacrylate) complex by controlling the permeation time of the methyl methacrylate monomer and polymerization initiator into the decellularized dermis. The mechanical strength of this complex gradually increased from the dermis side to the polymer side, and combined the physical characteristics of the dermis and the polymer.
KW - Absorption
KW - Decellularised dermis
KW - Gradient-type complex
KW - Interlinking device
KW - Sonication
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U2 - 10.1016/j.msec.2020.111017
DO - 10.1016/j.msec.2020.111017
M3 - Article
C2 - 32993989
AN - SCOPUS:85084179686
SN - 0928-4931
VL - 114
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 111017
ER -