Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions

Atsushi Ikeda, Tatsuya Sue, Motofusa Akiyama, Katsuyoshi Fujioka, Tamami Shigematsu, Yuki Doi, Jun Ichi Kikuchi, Toshifumi Konishi, Riichiro Nakajima

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

(Figure Presented) Fullerene-containing liposomes with high photosensitization ability were prepared. Disaggregated fullerenes were efficiently injected into the bilayer of liposomes by a phototriggered molecular exchange reaction. These liposomes showed far higher photoreactivity than liposomes thermally produced by heating and microwave irradiation. This result indicates that control of self-aggregation of fullerene leads to a high quantum yield for the photoreaction because of the suppression of self-quenching of photoexcited fullerenes.

Original languageEnglish
Pages (from-to)4077-4080
Number of pages4
JournalOrganic Letters
Volume10
Issue number18
DOIs
Publication statusPublished - 2008

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Fullerenes
Lipid bilayers
Liposomes
fullerenes
lipids
preparation
Photoreactivity
Microwave irradiation
Quantum yield
Quenching
Agglomeration
quenching
retarding
Heating
microwaves
irradiation
heating

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions. / Ikeda, Atsushi; Sue, Tatsuya; Akiyama, Motofusa; Fujioka, Katsuyoshi; Shigematsu, Tamami; Doi, Yuki; Kikuchi, Jun Ichi; Konishi, Toshifumi; Nakajima, Riichiro.

In: Organic Letters, Vol. 10, No. 18, 2008, p. 4077-4080.

Research output: Contribution to journalArticle

Ikeda, A, Sue, T, Akiyama, M, Fujioka, K, Shigematsu, T, Doi, Y, Kikuchi, JI, Konishi, T & Nakajima, R 2008, 'Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions', Organic Letters, vol. 10, no. 18, pp. 4077-4080. https://doi.org/10.1021/ol8015918
Ikeda, Atsushi ; Sue, Tatsuya ; Akiyama, Motofusa ; Fujioka, Katsuyoshi ; Shigematsu, Tamami ; Doi, Yuki ; Kikuchi, Jun Ichi ; Konishi, Toshifumi ; Nakajima, Riichiro. / Preparation of highly photosensitizing liposomes with fullerene-doped lipid bilayer using dispersion-controllable molecular exchange reactions. In: Organic Letters. 2008 ; Vol. 10, No. 18. pp. 4077-4080.
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