Production of tetrapyrrole compounds and vitamin B12 using genetically engineering of Propionibacterium freudenreichii. An overview

Yoshikatsu Murooka, Yongzhe Piao, Pornpimon Kiatpapan, Mitsuo Yamashita

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Propionibacterium freudenreichii is a commercially important bacterium that is used in the production of cheeses, cobalamin (vitamin B12) and propionic acid. Metabolic engineering using genetically improved strains will make the fermentation process more economical and also enhance the quality of the products. Host-vector systems and expression vectors using strong promoters from P. freudenreichii were developed in propionibacteria. By using these expression vectors and amplification of various genes, productions of 5-aminolevulinic acid, tetrapyrrole compounds and vitamin B12 were reported. Here, we review the advancement of genetic engineering in P. freudenreichii in recent years, covering the molecular aspects of the formation of tetrapyrrole compounds and vitamin B12.

Original languageEnglish
Pages (from-to)9-22
Number of pages14
JournalLait
Volume85
Issue number1-2
DOIs
Publication statusPublished - 2005 Jan
Externally publishedYes

Fingerprint

Propionibacterium freudenreichii
Tetrapyrroles
vitamin B12
Vitamin B 12
engineering
Metabolic engineering
Propionibacterium
gene amplification
Genetic engineering
Cheeses
Aminolevulinic Acid
aminolevulinic acid
metabolic engineering
propionic acid
genetic engineering
product quality
Fermentation
Amplification
cheeses
Bacteria

Keywords

  • Expression vector
  • Propionibacterium
  • Tetrapyrrole
  • Vitamin B

ASJC Scopus subject areas

  • Food Science

Cite this

Production of tetrapyrrole compounds and vitamin B12 using genetically engineering of Propionibacterium freudenreichii. An overview. / Murooka, Yoshikatsu; Piao, Yongzhe; Kiatpapan, Pornpimon; Yamashita, Mitsuo.

In: Lait, Vol. 85, No. 1-2, 01.2005, p. 9-22.

Research output: Contribution to journalArticle

Murooka, Yoshikatsu ; Piao, Yongzhe ; Kiatpapan, Pornpimon ; Yamashita, Mitsuo. / Production of tetrapyrrole compounds and vitamin B12 using genetically engineering of Propionibacterium freudenreichii. An overview. In: Lait. 2005 ; Vol. 85, No. 1-2. pp. 9-22.
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