Professor Toshio Ito

A clairvoyant in pericyte biology

Makoto Suematsu, Sadakazu Aiso

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Ito cells are liver-specific pericytes which were first described as Fett Speicherung Zellen, the fat-storing cells encircling outside sinusoidal endothelial cells, in 1951 by the late professor Toshio Ito. His pioneering approaches for morphological characterization of the cells stimulate investigators to further examine their functional roles in liver homeostasis: a body of evidence has been accumulated in recent years showing that the cells play a crucial role in storage and delivery of vitamin A, regulation of sinusoidal tone and local blood supply, and tissue repair and fibrosis. It is now widely accepted that microvascular pericytes including Ito cells serve as a key player that controls angiogenesis. Furthermore, recent studies support a concept that Ito cells constitutes a bridging apparatus mediating bidirectional metabolic interactions between sinusoids and hepatocytes, utilizing prostanoids and/or gaseous mediators such as nitric oxide and carbon monoxide as signaling molecules. This article reviews researches on this liver-specific pericyte and its leading roles in recent development of pericyte biology.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalKeio Journal of Medicine
Volume50
Issue number2
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Keywords

  • Carbon monoxide
  • Microcirculation
  • Pericytes
  • Soluble guanylate cyclase
  • Vitamin A

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Professor Toshio Ito : A clairvoyant in pericyte biology. / Suematsu, Makoto; Aiso, Sadakazu.

In: Keio Journal of Medicine, Vol. 50, No. 2, 01.01.2001, p. 66-71.

Research output: Contribution to journalReview article

@article{5629620e545a4355ad157a4137d8ae65,
title = "Professor Toshio Ito: A clairvoyant in pericyte biology",
abstract = "Ito cells are liver-specific pericytes which were first described as Fett Speicherung Zellen, the fat-storing cells encircling outside sinusoidal endothelial cells, in 1951 by the late professor Toshio Ito. His pioneering approaches for morphological characterization of the cells stimulate investigators to further examine their functional roles in liver homeostasis: a body of evidence has been accumulated in recent years showing that the cells play a crucial role in storage and delivery of vitamin A, regulation of sinusoidal tone and local blood supply, and tissue repair and fibrosis. It is now widely accepted that microvascular pericytes including Ito cells serve as a key player that controls angiogenesis. Furthermore, recent studies support a concept that Ito cells constitutes a bridging apparatus mediating bidirectional metabolic interactions between sinusoids and hepatocytes, utilizing prostanoids and/or gaseous mediators such as nitric oxide and carbon monoxide as signaling molecules. This article reviews researches on this liver-specific pericyte and its leading roles in recent development of pericyte biology.",
keywords = "Carbon monoxide, Microcirculation, Pericytes, Soluble guanylate cyclase, Vitamin A",
author = "Makoto Suematsu and Sadakazu Aiso",
year = "2001",
month = "1",
day = "1",
doi = "10.2302/kjm.50.66",
language = "English",
volume = "50",
pages = "66--71",
journal = "Keio Journal of Medicine",
issn = "0022-9717",
publisher = "Keio University School of Medicine",
number = "2",

}

TY - JOUR

T1 - Professor Toshio Ito

T2 - A clairvoyant in pericyte biology

AU - Suematsu, Makoto

AU - Aiso, Sadakazu

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Ito cells are liver-specific pericytes which were first described as Fett Speicherung Zellen, the fat-storing cells encircling outside sinusoidal endothelial cells, in 1951 by the late professor Toshio Ito. His pioneering approaches for morphological characterization of the cells stimulate investigators to further examine their functional roles in liver homeostasis: a body of evidence has been accumulated in recent years showing that the cells play a crucial role in storage and delivery of vitamin A, regulation of sinusoidal tone and local blood supply, and tissue repair and fibrosis. It is now widely accepted that microvascular pericytes including Ito cells serve as a key player that controls angiogenesis. Furthermore, recent studies support a concept that Ito cells constitutes a bridging apparatus mediating bidirectional metabolic interactions between sinusoids and hepatocytes, utilizing prostanoids and/or gaseous mediators such as nitric oxide and carbon monoxide as signaling molecules. This article reviews researches on this liver-specific pericyte and its leading roles in recent development of pericyte biology.

AB - Ito cells are liver-specific pericytes which were first described as Fett Speicherung Zellen, the fat-storing cells encircling outside sinusoidal endothelial cells, in 1951 by the late professor Toshio Ito. His pioneering approaches for morphological characterization of the cells stimulate investigators to further examine their functional roles in liver homeostasis: a body of evidence has been accumulated in recent years showing that the cells play a crucial role in storage and delivery of vitamin A, regulation of sinusoidal tone and local blood supply, and tissue repair and fibrosis. It is now widely accepted that microvascular pericytes including Ito cells serve as a key player that controls angiogenesis. Furthermore, recent studies support a concept that Ito cells constitutes a bridging apparatus mediating bidirectional metabolic interactions between sinusoids and hepatocytes, utilizing prostanoids and/or gaseous mediators such as nitric oxide and carbon monoxide as signaling molecules. This article reviews researches on this liver-specific pericyte and its leading roles in recent development of pericyte biology.

KW - Carbon monoxide

KW - Microcirculation

KW - Pericytes

KW - Soluble guanylate cyclase

KW - Vitamin A

UR - http://www.scopus.com/inward/record.url?scp=0035375650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035375650&partnerID=8YFLogxK

U2 - 10.2302/kjm.50.66

DO - 10.2302/kjm.50.66

M3 - Review article

VL - 50

SP - 66

EP - 71

JO - Keio Journal of Medicine

JF - Keio Journal of Medicine

SN - 0022-9717

IS - 2

ER -