Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats

Kei Ohwada, Hironobu Takeda, Makiko Yamazaki, Hirosi Isogai, Masahiko Nakano, Masao Shimomura, Koji Fukui, Shiro Urano

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ 10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ 10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant's interaction with vitamin E.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume42
Issue number1
DOIs
Publication statusPublished - 2008 Jan
Externally publishedYes

Fingerprint

coenzyme Q10
PQQ Cofactor
Oxidative stress
quinones
Rats
oxidative stress
Nutrition
rats
learning
hyperoxia
Data storage equipment
diet
Vitamin E
vitamin E
Rat control

Keywords

  • Coenzyme Q
  • Cognitive deficit
  • Oxidative stress
  • Pyrroloquinoline quinone

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Ohwada, K., Takeda, H., Yamazaki, M., Isogai, H., Nakano, M., Shimomura, M., ... Urano, S. (2008). Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats. Journal of Clinical Biochemistry and Nutrition, 42(1), 29-34. https://doi.org/10.3164/jcbn.2008005

Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats. / Ohwada, Kei; Takeda, Hironobu; Yamazaki, Makiko; Isogai, Hirosi; Nakano, Masahiko; Shimomura, Masao; Fukui, Koji; Urano, Shiro.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 42, No. 1, 01.2008, p. 29-34.

Research output: Contribution to journalArticle

Ohwada, Kei ; Takeda, Hironobu ; Yamazaki, Makiko ; Isogai, Hirosi ; Nakano, Masahiko ; Shimomura, Masao ; Fukui, Koji ; Urano, Shiro. / Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats. In: Journal of Clinical Biochemistry and Nutrition. 2008 ; Vol. 42, No. 1. pp. 29-34.
@article{836e7cc6c1f143d0a692c920947fc6a9,
title = "Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats",
abstract = "The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ 10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ 10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant's interaction with vitamin E.",
keywords = "Coenzyme Q, Cognitive deficit, Oxidative stress, Pyrroloquinoline quinone",
author = "Kei Ohwada and Hironobu Takeda and Makiko Yamazaki and Hirosi Isogai and Masahiko Nakano and Masao Shimomura and Koji Fukui and Shiro Urano",
year = "2008",
month = "1",
doi = "10.3164/jcbn.2008005",
language = "English",
volume = "42",
pages = "29--34",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "1",

}

TY - JOUR

T1 - Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats

AU - Ohwada, Kei

AU - Takeda, Hironobu

AU - Yamazaki, Makiko

AU - Isogai, Hirosi

AU - Nakano, Masahiko

AU - Shimomura, Masao

AU - Fukui, Koji

AU - Urano, Shiro

PY - 2008/1

Y1 - 2008/1

N2 - The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ 10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ 10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant's interaction with vitamin E.

AB - The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q10 (Co Q10), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ10-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improvement in the learning ability compared with the supplementation of PQQ alone. At the late stage of the test, rats fed PQQ-, CoQ10- and PQQ + CoQ10-supplemented diets showed similar improved learning abilities. When all the groups were subjected to hyperoxia as oxidative stress for 48 h, rats fed the PQQ- and CoQ 10 supplemented diets showed better memory function than the control rats. The concurrent diet markedly improved the memory deficit of the rats caused by oxidative stress. Although the vitamin E-deficient rats fed PQQ or CoQ10 improved their learning function even when subjected to hyperoxia, their memory function was maintained by PQQ rather than by CoQ 10 after the stress. These results suggest that PQQ is potentially effective for preventing neurodegeneration caused by oxidative stress, and that its effect is independent of either antioxidant's interaction with vitamin E.

KW - Coenzyme Q

KW - Cognitive deficit

KW - Oxidative stress

KW - Pyrroloquinoline quinone

UR - http://www.scopus.com/inward/record.url?scp=39149085638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149085638&partnerID=8YFLogxK

U2 - 10.3164/jcbn.2008005

DO - 10.3164/jcbn.2008005

M3 - Article

VL - 42

SP - 29

EP - 34

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 1

ER -