Rare earth metal ions for unprecedentedly fast RNA hydrolysis.

K. Matsumura, Y. Matsumoto, M. Komiyama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Adenylyl(3'-5')adenosine (ApA) and uridyl(3'-5')uridine (UpU) are hydrolyzed at unprecedentedly large rates by rare earth metal ions at pH 8, 30 degrees C. With 0.01 M Tm(III), the half-lives are 10 min and 51 min, respectively. Potentiality of these ions as catalytic center of artificial ribonuclease is proposed.

Original languageEnglish
Pages (from-to)11-12
Number of pages2
JournalNucleic acids symposium series
Issue number27
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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