RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy

Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Osamu Yamanoshita, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Yoshiyuki Kawamoto, Masashi Kato

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human melanomas, the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways are two major signaling pathways and are constitutively activated through genetic alterations. Mutations of RAF, RAS, and PTEN contribute to antiapoptosis, abnormal proliferation, angiogenesis, and invasion for melanoma development and progression. To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important. Here, we review MAPK and AKT signaling networks associated with melanoma development and progression.

Original languageEnglish
Article number354191
JournalDermatology Research and Practice
Volume2012
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

Cite this

Yajima, I., Kumasaka, M. Y., Thang, N. D., Goto, Y., Takeda, K., Yamanoshita, O., ... Kato, M. (2012). RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy. Dermatology Research and Practice, 2012, [354191]. https://doi.org/10.1155/2012/354191

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy. / Yajima, Ichiro; Kumasaka, Mayuko Y.; Thang, Nguyen Dinh; Goto, Yuji; Takeda, Kozue; Yamanoshita, Osamu; Iida, Machiko; Ohgami, Nobutaka; Tamura, Haruka; Kawamoto, Yoshiyuki; Kato, Masashi.

In: Dermatology Research and Practice, Vol. 2012, 354191, 01.12.2012.

Research output: Contribution to journalReview article

Yajima, I, Kumasaka, MY, Thang, ND, Goto, Y, Takeda, K, Yamanoshita, O, Iida, M, Ohgami, N, Tamura, H, Kawamoto, Y & Kato, M 2012, 'RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy', Dermatology Research and Practice, vol. 2012, 354191. https://doi.org/10.1155/2012/354191
Yajima, Ichiro ; Kumasaka, Mayuko Y. ; Thang, Nguyen Dinh ; Goto, Yuji ; Takeda, Kozue ; Yamanoshita, Osamu ; Iida, Machiko ; Ohgami, Nobutaka ; Tamura, Haruka ; Kawamoto, Yoshiyuki ; Kato, Masashi. / RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy. In: Dermatology Research and Practice. 2012 ; Vol. 2012.
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abstract = "Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human melanomas, the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways are two major signaling pathways and are constitutively activated through genetic alterations. Mutations of RAF, RAS, and PTEN contribute to antiapoptosis, abnormal proliferation, angiogenesis, and invasion for melanoma development and progression. To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important. Here, we review MAPK and AKT signaling networks associated with melanoma development and progression.",
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