Reactive oxygen species induce neurite degeneration before induction of cell death

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) induce neuronal call death in a time- and concentration-dependent manner. Treatment of cultured cells with a low concentration of hydrogen peroxide induces neurite degeneration, but not cell death. Neurites (axons and dendrites) are vulnerable to ROS. Neurite degeneration (shrinkage, accumulation, and fragmentation) has been found in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the mechanism of ROS-related neurite degeneration is not fully understood. Many studies have demonstrated the relationship between mitochondrial dysfunction and microtubule destabilization. These dysfunctions are deeply related to changes in calcium homeostasis and ROS production in neurites. Treatment with antioxidant substances, such as Vitamin E, prevents neurite degeneration in cultured cells. This review describes the possibility that ROS induces neurite degeneration before the induction of cell death.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Clinical Biochemistry and Nutrition
Volume59
Issue number3
DOIs
Publication statusPublished - 2016

Fingerprint

Cell death
Reactive Oxygen Species
Cells
Vitamin E
Hydrogen Peroxide
Antioxidants
Calcium

Keywords

  • Calcium
  • Mitochondria
  • Neurite degeneration
  • Neuron
  • ROS

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Reactive oxygen species induce neurite degeneration before induction of cell death. / Fukui, Koji.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 59, No. 3, 2016, p. 155-159.

Research output: Contribution to journalReview article

@article{ef45c629fdd24b7f827b9e1fd15f18e6,
title = "Reactive oxygen species induce neurite degeneration before induction of cell death",
abstract = "Reactive oxygen species (ROS) induce neuronal call death in a time- and concentration-dependent manner. Treatment of cultured cells with a low concentration of hydrogen peroxide induces neurite degeneration, but not cell death. Neurites (axons and dendrites) are vulnerable to ROS. Neurite degeneration (shrinkage, accumulation, and fragmentation) has been found in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the mechanism of ROS-related neurite degeneration is not fully understood. Many studies have demonstrated the relationship between mitochondrial dysfunction and microtubule destabilization. These dysfunctions are deeply related to changes in calcium homeostasis and ROS production in neurites. Treatment with antioxidant substances, such as Vitamin E, prevents neurite degeneration in cultured cells. This review describes the possibility that ROS induces neurite degeneration before the induction of cell death.",
keywords = "Calcium, Mitochondria, Neurite degeneration, Neuron, ROS",
author = "Koji Fukui",
year = "2016",
doi = "10.3164/jcbn.16-34",
language = "English",
volume = "59",
pages = "155--159",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "3",

}

TY - JOUR

T1 - Reactive oxygen species induce neurite degeneration before induction of cell death

AU - Fukui, Koji

PY - 2016

Y1 - 2016

N2 - Reactive oxygen species (ROS) induce neuronal call death in a time- and concentration-dependent manner. Treatment of cultured cells with a low concentration of hydrogen peroxide induces neurite degeneration, but not cell death. Neurites (axons and dendrites) are vulnerable to ROS. Neurite degeneration (shrinkage, accumulation, and fragmentation) has been found in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the mechanism of ROS-related neurite degeneration is not fully understood. Many studies have demonstrated the relationship between mitochondrial dysfunction and microtubule destabilization. These dysfunctions are deeply related to changes in calcium homeostasis and ROS production in neurites. Treatment with antioxidant substances, such as Vitamin E, prevents neurite degeneration in cultured cells. This review describes the possibility that ROS induces neurite degeneration before the induction of cell death.

AB - Reactive oxygen species (ROS) induce neuronal call death in a time- and concentration-dependent manner. Treatment of cultured cells with a low concentration of hydrogen peroxide induces neurite degeneration, but not cell death. Neurites (axons and dendrites) are vulnerable to ROS. Neurite degeneration (shrinkage, accumulation, and fragmentation) has been found in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the mechanism of ROS-related neurite degeneration is not fully understood. Many studies have demonstrated the relationship between mitochondrial dysfunction and microtubule destabilization. These dysfunctions are deeply related to changes in calcium homeostasis and ROS production in neurites. Treatment with antioxidant substances, such as Vitamin E, prevents neurite degeneration in cultured cells. This review describes the possibility that ROS induces neurite degeneration before the induction of cell death.

KW - Calcium

KW - Mitochondria

KW - Neurite degeneration

KW - Neuron

KW - ROS

UR - http://www.scopus.com/inward/record.url?scp=84994111948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994111948&partnerID=8YFLogxK

U2 - 10.3164/jcbn.16-34

DO - 10.3164/jcbn.16-34

M3 - Review article

AN - SCOPUS:84994111948

VL - 59

SP - 155

EP - 159

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 3

ER -