Abstract
A new and general method of iodine-mediated cyclization reactions of unsaturated carbamates, ureas and amides which gives N-cyclized products as a single regio-isomer was achieved. The present reaction proceeds in good yield through regio-control of an ambident nucleophile by LiAl(Ot-Bu)4, and the regio-control (N-attack vs O-attack) was also found to be remarkably affected by the additive employed.
Original language | English |
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Pages (from-to) | 615-618 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 38 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1997 Jan 27 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry