Abstract
A new and general method of iodine-mediated cyclization reactions of unsaturated carbamates, ureas and amides which gives N-cyclized products as a single regio-isomer was achieved. The present reaction proceeds in good yield through regio-control of an ambident nucleophile by LiAl(Ot-Bu)4, and the regio-control (N-attack vs O-attack) was also found to be remarkably affected by the additive employed.
| Original language | English |
|---|---|
| Pages (from-to) | 615-618 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1997 Jan 27 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Kitagawa, O., Fujita, M., Li, H., & Taguchi, T. (1997). Regio-controlled iodoaminocyclization reaction of an ambident nucleophile mediated by LiAl(Ot-Bu)4. Tetrahedron Letters, 38(4), 615-618. https://doi.org/10.1016/S0040-4039(96)02405-7