Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats

Nozomi Aruga, Megumi Toriigahara, Masahiro Shibata, Takeshi Ishii, Tsutomu Nakayama, Naomi Osakabe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (-)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalJournal of Functional Foods
Volume10
DOIs
Publication statusPublished - 2014 Sep 1

Fingerprint

hemodynamics
polyphenols
flavanols
theaflavins
rats
dosage
chemical structure
hesperidin
curcumin
daidzein
epigallocatechin
resveratrol
cyanidin
quercetin
arteries
blood flow
blood pressure
lasers
heart rate
ingestion

Keywords

  • Cremaster artery
  • Cremaster muscle
  • Microcirculation
  • Polyphenols
  • Systemic circulation

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats. / Aruga, Nozomi; Toriigahara, Megumi; Shibata, Masahiro; Ishii, Takeshi; Nakayama, Tsutomu; Osakabe, Naomi.

In: Journal of Functional Foods, Vol. 10, 01.09.2014, p. 355-363.

Research output: Contribution to journalArticle

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