Abstract
Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (-)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures.
| Original language | English |
|---|---|
| Pages (from-to) | 355-363 |
| Number of pages | 9 |
| Journal | Journal of Functional Foods |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 2014 Sep 1 |
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Keywords
- Cremaster artery
- Cremaster muscle
- Microcirculation
- Polyphenols
- Systemic circulation
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats. / Aruga, Nozomi; Toriigahara, Megumi; Shibata, Masahiro; Ishii, Takeshi; Nakayama, Tsutomu; Osakabe, Naomi.
In: Journal of Functional Foods, Vol. 10, 01.09.2014, p. 355-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats
AU - Aruga, Nozomi
AU - Toriigahara, Megumi
AU - Shibata, Masahiro
AU - Ishii, Takeshi
AU - Nakayama, Tsutomu
AU - Osakabe, Naomi
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (-)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures.
AB - Numerous studies suggest that the ingestion of polyphenols can potentially confer haemodynamic benefits. The association between different polyphenolic chemical structures and their physiologic effects on systemic haemodynamic variables and microcirculation are less well known. This study investigated the effects of a single 10 mg/kg body weight dose of different polyphenolic compounds on haemodynamic and microcirculatory parameters. Key results from laser Doppler flowmetry showed that flavan-3-ols, theaflavins, and quercetin significantly increased cremaster artery blood flow. Flavan 3-ols, theaflavins, (-)-epicatchin, daidzein, and cyanidin significantly elevated mean blood pressure, and flavan-3-ols significantly increased the heart rate. In contrast, hesperidin, epigallocatechin gallate, trans-resveratrol, gnetin C or curcumin did not result in any detectable changes. Our results suggest that polyphenols can contribute variably to alterations in the haemodynamic and microcirculatory status in rats depending on their characteristic chemical structures.
KW - Cremaster artery
KW - Cremaster muscle
KW - Microcirculation
KW - Polyphenols
KW - Systemic circulation
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UR - http://www.scopus.com/inward/citedby.url?scp=84920052340&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2014.06.025
DO - 10.1016/j.jff.2014.06.025
M3 - Article
AN - SCOPUS:84920052340
VL - 10
SP - 355
EP - 363
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -