Shear wave speed measurement bias in a viscoelastic phantom across six ultrasound elastography systems: a comparative study with transient elastography and magnetic resonance elastography

Riwa Kishimoto, Mikio Suga, Masashi Usumura, Hiroko Iijima, Masahiro Yoshida, Hiroyuki Hachiya, Tsuyoshi Shiina, Makoto Yamakawa, Kei Konno, Takayuki Obata, Tadashi Yamaguchi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To quantify the bias of shear wave speed (SWS) measurements in a viscoelastic phantom across six different ultrasound (US) systems and to compare the SWS with those from transient elastography (TE) and magnetic resonance elastography (MRE). Methods: A viscoelastic phantom of stiffness representing fibrotic liver or healthy thyroid was measured with nine (linear probe) and 10 (convex probe) modes of six different US-based shear wave elastography (SWE) systems using linear and convex probes. SWS measurements of three regions of interest were repeated thrice at two focal depths, coupling the probe to the phantom using a jig. An MRE system using three motion-encoding gradient frequencies of 60, 90, and 120 Hz and TE were also used to measure the stiffness of the phantom. Results: The SWS from different SWE systems had mean coefficients of variation of 9.0–9.2% and 5.4–5.6% with linear and convex probes, respectively, in viscoelastic phantom measurement. The focal depth was a less significant source of SWS variability than the system. The total average SWS obtained with US-SWE systems was 19.9% higher than that obtained with MRE at 60 Hz, which is commonly used in clinical practice, and 31.5% higher than that obtained with TE using the M probe. Conclusions: Despite the measurement biases associated with the SWE systems, biases were not necessarily consistent, and they changed with the probes used and depth measured. The SWS of the viscoelastic phantom obtained using different modalities increased according to the shear wave frequency used.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalJournal of Medical Ultrasonics
Volume49
Issue number2
DOIs
Publication statusPublished - 2022 Apr
Externally publishedYes

Keywords

  • Magnetic resonance elastography
  • Phantom
  • Quantitative imaging biomarker alliance
  • Ultrasound elastography
  • Viscoelasticity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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