Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation

Jin Nakahara, Kyoko Tan-Takeuchi, Chika Seiwa, Mari Gotoh, Tomonori Kaifu, Azusa Ujike, Masanori Inui, Takeshi Yagi, Masaharu Ogawa, Sadakazu Aiso, Toshiyuki Takai, Hiroaki Asou

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Dramatic changes in morphology and myelin protein expression take place during the differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes. Fyn tyrosine kinase was reported to play a central role in the differentiation process. Molecules that could induce Fyn signaling have not been studied. Such molecules are promising therapeutic targets in demyelinating diseases. We provide evidence that the common γ chain of immunoglobulin Fc receptors (FcRγ) is expressed in OPCs and has a role in triggering Fyn signaling. FcRγ cross-linking by immunoglobulin G on OPCs promotes the activation of Fyn signaling and induces rapid morphological differentiation with upregulation of myelin basic protein (MBP) expression levels. Mice deficient in FcRγ are hypomyelinated, and a significant reduction in MBP content is evident. Our findings indicate that the FcRγ-Fyn-MBP cascade is pivotal during the differentiation of OPCs into myelinating oligodendrocytes, revealing an unexpected involvement of immunological molecules.

Original languageEnglish
Pages (from-to)841-852
Number of pages12
JournalDevelopmental Cell
Volume4
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1
Externally publishedYes

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Fc Receptors
Myelin Basic Protein
Molecules
Proto-Oncogene Proteins c-fyn
Immunoglobulin Subunits
Myelin Proteins
Immunoglobulin G
Chemical activation

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Nakahara, J., Tan-Takeuchi, K., Seiwa, C., Gotoh, M., Kaifu, T., Ujike, A., ... Asou, H. (2003). Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation. Developmental Cell, 4(6), 841-852. https://doi.org/10.1016/S1534-5807(03)00155-2

Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation. / Nakahara, Jin; Tan-Takeuchi, Kyoko; Seiwa, Chika; Gotoh, Mari; Kaifu, Tomonori; Ujike, Azusa; Inui, Masanori; Yagi, Takeshi; Ogawa, Masaharu; Aiso, Sadakazu; Takai, Toshiyuki; Asou, Hiroaki.

In: Developmental Cell, Vol. 4, No. 6, 01.06.2003, p. 841-852.

Research output: Contribution to journalArticle

Nakahara, J, Tan-Takeuchi, K, Seiwa, C, Gotoh, M, Kaifu, T, Ujike, A, Inui, M, Yagi, T, Ogawa, M, Aiso, S, Takai, T & Asou, H 2003, 'Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation', Developmental Cell, vol. 4, no. 6, pp. 841-852. https://doi.org/10.1016/S1534-5807(03)00155-2
Nakahara, Jin ; Tan-Takeuchi, Kyoko ; Seiwa, Chika ; Gotoh, Mari ; Kaifu, Tomonori ; Ujike, Azusa ; Inui, Masanori ; Yagi, Takeshi ; Ogawa, Masaharu ; Aiso, Sadakazu ; Takai, Toshiyuki ; Asou, Hiroaki. / Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation. In: Developmental Cell. 2003 ; Vol. 4, No. 6. pp. 841-852.
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